PMID: 9434797Jan 22, 1998Paper

Gender and androgen treatment influence the expression of proto-oncogenes and apoptotic factors in lacrimal and salivary tissues of MRL/lpr mice

Clinical Immunology and Immunopathology
I TodaD A Sullivan

Abstract

The objectives of this study were to (1) determine whether Fas antigen, Fas ligand, p53, and proto-oncogene mRNAs may be detected in lacrimal and submandibular glands of the MRL/lpr mouse model of Sjögren's syndrome, and (2) examine whether gender and androgen or cyclophosphamide therapy influence the mRNA expression of these apoptotic factors. Tissues were obtained from treated or untreated MRL/lpr mice after the onset of disease and processed for the analysis of mRNAs by RT-PCR and Southern blot hybridization. Our results demonstrated that (1) Fas antigen (exons 1-->2 or 3-->7+), Fas ligand, c-myb, c-myc, bcl-2, Bax, p53, and androgen receptor (AR) mRNAs are present in exocrine tissues of MRL/lpr mice; (2) the amounts of c-myb, c-myc, bcl-2, p53, and AR mRNA are higher (P < 0.05) and the level of Fas antigen (exons 1-->2) mRNA is lower (P < 0.05) in lacrimal glands of female compared to male mice. In contrast, the content of c-myb and p53 mRNA is greater (P < 0.05) in submandibular tissues of female relative to those of male mice; and (3) testosterone or cyclophosphamide treatment led to a significant (P < 0.05) decline in the mRNA levels of c-myb, bcl-2, and/or AR, but an increase (P < 0.05) in the mRNA amount of Bax, in lac...Continue Reading

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Citations

Feb 16, 1999·Journal of Cellular Physiology·B HaendlerW D Schleuning
Jul 14, 1999·Arthritis and Rheumatism·N I TapinosH M Moutsopoulos
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Nov 28, 2018·Investigative Ophthalmology & Visual Science·Sara TellefsenDavid A Sullivan
Jul 13, 2002·Annals of the New York Academy of Sciences·David A SullivanM Reza Dana
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Dec 1, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R I FoxA Fisher
Jun 28, 2005·Experimental Eye Research·Stephen M RichardsDavid A Sullivan

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