Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings

European Heart Journal
M Stramba-BadialePeter J Schwartz

Abstract

There are gender-related differences in the QT interval measured from standard ECG tracings. However, these observations are based on a limited number of beats recorded in resting conditions. Computerized Holter techniques enable ventricular repolarization and its relationship with cardiac cycle length to be analysed long term. Previous studies used only the initial portion of the QT interval to the T wave apex (QTa) to measure ventricular repolarization; however, QTa may underestimate the total QT duration (QTe). The aims of this study were to verify whether QTa and QTe had similar rate-dependence in normal subjects and whether gender-related QTe differences observed in the resting ECG were also present in the long-term QT intervalcycle length relationship. Twenty-four hour Holter recordings were obtained in 40 healthy young subjects. 20 females and 20 males (mean age 28 +/- 9 and 26 +/- 5 years, respectively ns). Two-channel ECG digitized signals were processed using new automatic QT analysis software (Ela Medical), which converted the 24-h recordings into 2880 30-s templates. It also measured the QT apex (QTa) QT end (QTe) and the RR interval (ms) of each template, and computed the slopes of the linear regressions of QTe and...Continue Reading

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