Gender and vesico-ureteral reflux: a multivariate analysis

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Jose Maria Penido SilvaDaniela Espirito Santo

Abstract

The aim of this retrospective cohort study was to describe the characteristics of patients with primary vesico-ureteral reflux (VUR) with special attention to gender-specific differences. Between 1970 and 2004, 735 patients were diagnosed with VUR and were systematically followed in a single tertiary renal unit. The following variables were analyzed: race, age at diagnosis, clinical presentation, weight and height Z-score, unilateral/bilateral reflux, VUR grade, renal damage, severity of renal damage, constipation, and dysfunctional voiding. Comparison of proportion between genders was assessed by the chi-square test with Yates' correction. The logistic regression model was applied to identify independent variables associated with gender. A survival analysis was performed to evaluate VUR resolution. After adjustment, five variables remained independently associated with male gender at baseline: non-white race [Odds ratio (OR) = 1.98, 95% confidence interval (95% CI) 1.33-2.95, P=0.001], moderate/severe grade of reflux (OR=2.16, 95% CI 1.45-3.22, P<0.001), severe renal damage (OR=1.60, 95% CI 1.04-2.52, P=0.04), age at diagnosis <24 months (OR=1.79, 95% CI 1.23-2.60, P=0.002), and antenatal clinical presentation (OR=3.56, 95% CI...Continue Reading

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Citations

Jan 11, 2007·Pediatric Surgery International·Seika Kuroda, Prem Puri
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jose Maria Penido SilvaEduardo Araujo Oliveira
Jun 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jose Maria Penido SilvaEduardo Araujo Oliveira
Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Constantinos J Stefanidis, Ekaterini Siomou
Aug 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D MarksKjell Tullus
Sep 27, 2007·Nature Clinical Practice. Nephrology·Patricio C Gargollo, David A Diamond
May 1, 2008·Nature Clinical Practice. Nephrology·Larissa KerecukAdrian S Woolf
Feb 18, 2011·American Journal of Physiology. Renal Physiology·Jose ParedesCarlton M Bates
Oct 20, 2007·Current Medical Research and Opinion·Terry W Hensle, Amy L Grogg
Sep 3, 2010·Seminars in Nephrology·Hakan R TokaHiep T Nguyen
Jan 3, 2013·Acta Paediatrica·Caroline CaillaudMichel Fischbach
Feb 24, 2009·The Journal of School Nursing : the Official Publication of the National Association of School Nurses·Mary Kistner
Apr 9, 2011·Current Opinion in Urology·Fernando CarvasHiep T Nguyen
Mar 9, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasikar MurugapoopathyIndra R Gupta
Jun 15, 2007·Current Opinion in Urology

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