Gender aspects of CGRP in migraine

Cephalalgia : an International Journal of Headache
Alejandro Labastida-RamírezAntoinette MaassenVanDenBrink

Abstract

Migraine is two to three times more prevalent in women than in men, but the mechanisms involved in this gender disparity are still poorly understood. In this respect, calcitonin gene-related peptide (CGRP) plays a key role in migraine pathophysiology and, more recently, the functional interactions between ovarian steroid hormones, CGRP and the trigeminovascular system have been recognized and studied in more detail. To provide an overview of CGRP studies that have addressed gender differences utilizing animal and human migraine preclinical research models to highlight how the female trigeminovascular system responds differently in the presence of varying ovarian steroid hormones. Gender differences are evident in migraine. Several studies indicate that fluctuations of ovarian steroid hormone (mainly estrogen) levels modulate CGRP in the trigeminovascular system during different reproductive milestones. Such interactions need to be considered when conducting future animal and human experiments, since these differences may contribute to the development of gender-specific therapies.

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Citations

May 6, 2019·The Journal of Headache and Pain·Alejandro Labastida-RamírezAntoinette MaassenVanDenBrink
May 17, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Gabriele S Merki-FeldPeter Sandor
Jan 25, 2020·Pain·Alejandro Labastida-RamírezAntoinette MaassenVanDenBrink
Nov 23, 2019·Practical Neurology·Shazia K Afridi
Jul 22, 2020·Cephalalgia : an International Journal of Headache·Håkan AshinaHenrik Winther Schytz
Dec 1, 2018·The Journal of Headache and Pain·Zoë DelaruelleUNKNOWN European Headache Federation School of Advanced Studies (EHF-SAS)
May 29, 2018·The Journal of Headache and Pain·Kristian A HaanesAntoinette MaassenVanDenBrink
Aug 5, 2020·The Journal of Headache and Pain·Jelena M PavlovicDaniel D Mikol
Aug 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gianni AllaisChiara Benedetto
Dec 21, 2019·Cephalalgia : an International Journal of Headache·Erika Ivanna ArayaJuliana Geremias Chichorro
Oct 23, 2020·Cephalalgia : an International Journal of Headache·Katie M LinstraAntoinette MaassenVanDenBrink
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Nov 6, 2021·Expert Review of Neurotherapeutics·Enrico BentivegnaPaolo Martelletti
Jan 31, 2022·Lancet Neurology·Linda Al-HassanyAntoinette MaassenVanDenBrink

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