Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years

PloS One
Myoungsook LeeHye Kyung Park

Abstract

High sodium intake is associated with the development of chronic diseases such as obesity. Although its role in obesity remains controversial, there may be a correlation between salt sensitivity and the early onset of chronic diseases in obese children. In all, 2,163 Korean children (1,106 boys and 1,057 girls) aged 8-9 years were recruited from seven elementary schools in Seoul. To evaluate whether obesity risk was modulated by the salt sensitivity, 11 SNPs related to salt sensitive genes (SSG) became the target of sodium intakes in obese children. BP, HOMA-IR, LDLc, TG, and the girls' sodium intake significantly increased, but HDLc significantly decreased with increase in BMI. Regardless of sex, the obesity risk was 5.27-fold (CI; 1.320-27.560) higher in the Q2 to Q5 of sodium intake adjusted by energy (4044.9-5058.9 mg/day) than in the lowest Q1 level (2287.6 mg/day) in obese children. BP was sensitively dependent on insulin resistance and lipid accumulation in all subjects; however, sodium intake may be an independent risk factor of obesity without increasing BP in girls. GRK4 A486V mutant homozygote was highly distributed in the obese group, but other SNPs had no impact. The obesity risk increased 7.06, 16.8, and 46.09-fol...Continue Reading

References

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Citations

Mar 2, 2016·American Journal of Hypertension·Wakako Kawarazaki, Toshiro Fujita
Nov 4, 2016·Epigenomics·Trine B RoungeElisabete Weiderpass
Apr 6, 2016·Hypertension·Pedro A JoseGilbert M Eisner
Jul 23, 2019·Western Journal of Nursing Research·Jisan LeeLee Hyeoiyun
Dec 10, 2019·Nutrition Research and Practice·Myoungsook Lee
Dec 27, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M LeeJ Park
Oct 23, 2020·Current Hypertension Reports·Jessica L Faulkner, Eric J Belin de Chantemèle
Feb 6, 2021·Journal of Personalized Medicine·Myoungsook LeeSungbin R Sorn

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Methods Mentioned

BETA
ELISA

Software Mentioned

CanPro SW
CAN
Pro
SNaPShot
SAS

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