Gender, blood pressure, and cardiovascular and renal outcomes in adults with hypertension from the Systolic Blood Pressure Intervention Trial

Journal of Hypertension
Capri G FoySPRINT Study Research Group

Abstract

To determine if the effects of intensive lowering of systolic blood pressure (goal of less than 120 mmHg) versus standard lowering (goal of less than 140 mmHg) upon cardiovascular, renal, and safety outcomes differed by gender. Nine thousand three hundred and sixty-one men and women aged 50 years or older with systolic blood pressure of 130 mmHg or greater, taking 0-4 antihypertensive medications, and with increased risk of cardiovascular disease, but free of diabetes, were randomly assigned to either a systolic blood pressure target of less than 120 mmHg (intensive treatment) or a target of less than 140 mmHg (standard treatment). The primary composite outcome encompassed incident myocardial infarction, heart failure, other acute coronary syndromes, stroke, or cardiovascular-related death. All-cause mortality, renal outcomes, and serious adverse events were also assessed. Compared with the standard treatment group, the primary composite outcome in the intensive treatment group was reduced by 16% [hazard ratio 0.84 (0.61-1.13)] in women, and by 27% in men [hazard ratio 0.73 (0.59-0.89), P value for interaction between treatment and gender is 0.45]. Similarly, the effect of the intensive treatment on individual components of the...Continue Reading

Associated Clinical Trials

Sep 21, 2010·David Reboussin, David Reboussin

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Citations

Oct 10, 2018·American Journal of Hypertension·Lindsey A Ramirez, Jennifer C Sullivan
Aug 28, 2019·Current Hypertension Reports·Yasmin BrahmbhattSeyed Hamrahian
Sep 10, 2020·Journal of Cardiovascular Pharmacology·Vanessa Dela JustinaR Clinton Webb
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Jul 8, 2021·Journal of Human Hypertension·Paul J ConnellyChristian Delles

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