PMID: 11933052Apr 5, 2002Paper

Gender-dependent hypoxic tolerance mediated via gender-specific mechanisms

Journal of Neuroscience Research
C A von ArnimM W Riepe

Abstract

Primary hypoxic tolerance and preconditioning are gender dependent and modulated in females during the estrus cycle. The underlying mechanisms, however, remain to be determined. mRNA of estrogen receptor-alpha (EAR), progesterone receptor (PR), and adenosine receptor subtypes A1 and A3 (A1R and A3R) were investigated with reverse transcriptase-PCR in hippocampi from control male and female mice and animals treated in vivo with a single i.p. injection of 20 mg/kg body weight 3-nitropropionate (3NP) 1 or 24 hr prior to preparation. Results were analyzed relative to expression in hippocampi from untreated males. mRNA levels of EAR and A1R were alike in males and females and unaltered by preconditioning with 3NP. In contrast, PR mRNA levels were alike in males and females during proestrus but lower during estrus and diestrus (85% +/- 15%, P < 0.05; and 80% +/- 10%, P < 0.05, respectively). Upon preconditioning, PR mRNA decreased to 67% +/- 19% (P < 0.05) and 56% +/- 13% (P < 0.05) during proestrus and diestrus, respectively, but was unaltered during estrus and in males. On preconditioning, A3R mRNA decreased from 115% +/- 16% to 86% +/- 29% (P < 0.05) during diestrus but remained at the control level during proestrus and estrus. Wi...Continue Reading

References

Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C HeurteauxM Lazdunski
Dec 1, 1996·Neuroscience·M A Pérez-PinzónT J Sick
Mar 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M W RiepeJ Hugon
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·N J AlkayedP D Hurn
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D B DubalP M Wise
Jun 4, 1999·Stroke; a Journal of Cerebral Circulation·K KasischkeM W Riepe
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·R RusaP D Hurn
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C CulmseeJ Krieglstein
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M SawadaP D Hurn
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·N J AlkayedV M Miller
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·K SampeiP D Hurn
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P H McNultyT Caulin-Glaser
May 8, 2000·Stroke; a Journal of Cerebral Circulation·S J MurphyS P Duckles
Jan 11, 2000·Stroke; a Journal of Cerebral Circulation·M I RossbergP D Hurn
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·D B DubalP M Wise
Aug 31, 2001·Journal of the American College of Cardiology·H J RankiA Jovanović

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Citations

Feb 22, 2005·Basic Research in Cardiology·Guro Valen, Jarle Vaage
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck
Jan 16, 2008·CNS Drugs·Matthias W Riepe, Roman Huber
Jul 10, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lan WangStephanie J Murphy
Nov 4, 2015·Respiratory Physiology & Neurobiology·Jean-Philippe RousseauRichard Kinkead
Feb 6, 2004·Journal of Neurochemistry·David LeónMairena Martín
Jul 13, 2004·Neuroscience Letters·C A F von ArnimM W Riepe
Sep 26, 2006·Neurobiology of Aging·Philipp T MeyerAndreas Bauer
Nov 9, 2005·Mechanisms of Ageing and Development·C A F von ArnimM W Riepe
Feb 1, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideto KitanoStephanie J Murphy
Apr 20, 2016·Journal of the American Heart Association·Satoshi YoshinoAmir Lerman
Jan 25, 2020·Conservation Physiology·Andrea J MorashJayson M Semmens

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