Gender difference in the effect of progesterone on neonatal hypoxic/ischemic brain injury in mouse

Experimental Neurology
Shuyu DongFang Hua

Abstract

This study investigated the effects of progesterone (PROG) on neonatal hypoxic/ischemic (NHI) brain injury, the differences in effects between genders, and the underlying mechanisms. NHI brain injury was established in both male and female neonatal mice induced by occlusion of the left common carotid artery followed by hypoxia. The mice were treated with PROG or vehicle. Fluoro-Jade B staining (F-JB), long term behavior testing, and brain magnetic resonance image (MRI) were applied to evaluate neuronal death, neurological function, and brain damage. The underlying molecular mechanisms were also investigated by Western blots. The results showed that, in the male mice, administration of PROG significantly reduced neuronal death, improved the learning and memory function impaired by cerebral HI, decreased infarct size, and maintained the thickness of the cortex after cerebral HI. PROG treatment, however, did not show significant neuroprotective effects on female mice subjected to HI. In addition, the data demonstrated a gender difference in the expression of tumor necrosis factor receptor 1 (TNFR1), TNF receptor associated factor 6 (TRAF6), Fas associated protein with death domain (FADD), and TIR-domain-containing adapter-inducing...Continue Reading

Citations

Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Verena Theis, Carsten Theiss
Aug 6, 2019·Frontiers in Pediatrics·Ramin P La GardeGeorg M Schmölzer
Mar 15, 2020·Cellular and Molecular Neurobiology·Rafael Bandeira FabresLuciano Stürmer de Fraga
Jan 9, 2021·Journal of Neuroscience Research·Rongjiao ShaoDerong Cui
Nov 16, 2020·Frontiers in Neuroendocrinology·Maddalena Sparaco, Simona Bonavita
Aug 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zeinab VahidiniaMohammad Taghi Joghataei

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