Abstract
To investigate the interaction effects of diabetes and hypertension on stroke, and also investigate the independent and interaction effects of parental history and environmental factors on diabetes and hypertension in a cross-sectional elderly population. The Shih-Pai Community Medical Service Program was a community-based, fixed cohort study conducted between June 1999 and November 2002. Socio-demographic and clinical data of subjects aged 65 years and older were collected by well-trained interviewers during home visits. Interaction effects were analyzed using Rothman's synergy index (SI). In total, 4,124 subjects were included in the study, with 2,284 males and 1,840 females. The synergistic interaction of diabetes and hypertension on stroke was statistically significant in women (SI = 3.16, 95% CI: 1.35-7.39). The synergistic interaction of parental diabetes and being overweight on diabetes was only statistically significant in men, and not in women (SI = 3.30, 95% CI: 1.00-10.83 in men, and SI = 1.15, 95% CI: 0.30-4.39 in women). A synergistic interaction was found for diabetes and hypertension in both sexes when parental history and being overweight were combined. Furthermore, combining diabetes and hypertension in elderly...Continue Reading
References
Sep 1, 1995·Epidemiology·M J Khoury, W D Flanders
Jun 20, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P S TsaoG M Reaven
Apr 7, 1999·American Journal of Hypertension·R B SimsoloB Grunfeld
Dec 16, 2000·Diabetes·J B MeigsP W Wilson
Feb 24, 2001·Diabetologia·E A Gale, K M Gillespie
Feb 5, 2002·Archives of Internal Medicine·Christa MeisingerHannelore Löwel
Nov 6, 2004·Journal of Clinical Epidemiology·Yuji OkuraRichard J Rodeheffer
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
Jul 8, 2005·Magma·J MachannF Schick
Aug 27, 2005·European Journal of Epidemiology·Tomas AnderssonAnders Ahlbom
Nov 12, 2005·Stroke; a Journal of Cerebral Circulation·Gang HuJaakko Tuomilehto
Jul 14, 2007·Diabetes Care·Louise A KellyMichael I Goran
Oct 27, 2007·Climacteric : the Journal of the International Menopause Society·C VitaleG M C Rosano
Aug 30, 2008·Lancet Neurology·Mathew J ReevesLynda Lisabeth
Jan 6, 2009·Hormones : International Journal of Endocrinology and Metabolism·Adeela ShahidMuhammad Arslan
Nov 13, 2009·Diabetes Care·Robert H Fagard
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Andrea NataliUNKNOWN Relationship between Insulin Sensitivity and Cardiovascular disease investigators
Dec 4, 2010·Obesity Surgery·Ninh T NguyenPing Wang
Oct 4, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Roy A M HaastAmanda J Kiliaan
Oct 12, 2012·Diabetologia·UNKNOWN InterAct ConsortiumN J Wareham
Nov 10, 2012·Maturitas·Seung Ji LimHeechoul Ohrr
May 1, 2013·PloS One·Cecilia WiknerKarin Leander
Aug 2, 2013·Diabetes Care·Valeriya Lyssenko, Markku Laakso
Sep 28, 2013·Canadian Journal of Diabetes·Feng NingUNKNOWN Qingdao 2006 Diabetes Survey and FINRISK 2002 Study
Mar 13, 2014·Lancet·Sanne A E PetersMark Woodward
Sep 3, 2014·Annals of Internal Medicine·Andy MenkeCatherine C Cowie
Sep 12, 2014·Circulation·Susan ChengScott D Solomon
Citations
Dec 17, 2016·International Journal of Environmental Research and Public Health·Xueyuan ZhiGuifan Sun
Feb 14, 2018·Stroke; a Journal of Cerebral Circulation·Tracy E MadsenSeemant Chaturvedi
Aug 14, 2019·Hypertension·Tracy E MadsenVirginia J Howard
Nov 13, 2019·PloS One·Ming-Hung LinJong-Yi Wang
Dec 12, 2018·JAMA Neurology·Virginia J HowardMary Cushman
Nov 11, 2020·Metabolic Syndrome and Related Disorders·Taiwo H RaimiOladimeji A Ajayi
Jun 27, 2021·BMC Public Health·Zhehui WangHanlin Fu