Gender Difference in the Interaction Effects of Diabetes and Hypertension on Stroke among the Elderly in the Shih-Pai Study, Taiwan

PloS One
Yun-Ju LaiPesus Chou

Abstract

To investigate the interaction effects of diabetes and hypertension on stroke, and also investigate the independent and interaction effects of parental history and environmental factors on diabetes and hypertension in a cross-sectional elderly population. The Shih-Pai Community Medical Service Program was a community-based, fixed cohort study conducted between June 1999 and November 2002. Socio-demographic and clinical data of subjects aged 65 years and older were collected by well-trained interviewers during home visits. Interaction effects were analyzed using Rothman's synergy index (SI). In total, 4,124 subjects were included in the study, with 2,284 males and 1,840 females. The synergistic interaction of diabetes and hypertension on stroke was statistically significant in women (SI = 3.16, 95% CI: 1.35-7.39). The synergistic interaction of parental diabetes and being overweight on diabetes was only statistically significant in men, and not in women (SI = 3.30, 95% CI: 1.00-10.83 in men, and SI = 1.15, 95% CI: 0.30-4.39 in women). A synergistic interaction was found for diabetes and hypertension in both sexes when parental history and being overweight were combined. Furthermore, combining diabetes and hypertension in elderly...Continue Reading

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Citations

Dec 17, 2016·International Journal of Environmental Research and Public Health·Xueyuan ZhiGuifan Sun
Feb 14, 2018·Stroke; a Journal of Cerebral Circulation·Tracy E MadsenSeemant Chaturvedi
Nov 13, 2019·PloS One·Ming-Hung LinJong-Yi Wang
Nov 11, 2020·Metabolic Syndrome and Related Disorders·Taiwo H RaimiOladimeji A Ajayi

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