Gender Differences in Axial Spondyloarthritis: Women Are Not So Lucky

Current Rheumatology Reports
T RusmanIrene E van der Horst-Bruinsma

Abstract

Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gender distribution. The purpose of this review is to aggregate the existing data on gender differences in axSpA in order to increase the awareness that female axSpA patients are still under-recognized. Several studies considering gender differences revealed that female axSpA patients had different disease manifestations due to different immunological, hormonal, and genetic responses. For instance, allelic frequencies of the AHNK-gene and tissue non-specific alkaline phosphatase (TNAP) haplotypes differed between men and women with ankylosing spondylitis (AS). In addition, different levels of tumor necrosis factor (TNF), interleukins IL-6, IL-17, and IL-18, were found between the two sexes. Furthermore, female patients show a higher diagnostic delay compared to males. Several studies indicate a higher frequency of extra-articular manifestations (EAM) in female axSpA patients, such as enthesitis, psoriasis, and inflammatory bowel disea...Continue Reading

References

Jun 1, 1976·Annals of the Rheumatic Diseases·H F HillJ G Bodmer
Dec 1, 1992·Arthritis and Rheumatism·L D CarboneL J Melton
Jul 23, 1999·Annals of the New York Academy of Sciences·E J GiltayB A Dijkmans
Jul 26, 2000·Current Opinion in Rheumatology·E FeldtkellerM A Khan
May 19, 2005·Arthritis Research & Therapy·Hing Wo TsuiFlorence W L Tsui
Sep 27, 2005·Clinical Endocrinology·Teoman AydinZerrin Sahin
Nov 28, 2006·Annals of the Rheumatic Diseases·Wonuk LeeMichael H Weisman
Dec 30, 2006·Arthritis and Rheumatism·Hing Wo TsuiFlorence W L Tsui
May 4, 2007·Rheumatology International·Valerie AloushOri Elkayam
Oct 6, 2007·Internal Medicine Journal·M D ReedL Schachna
Feb 20, 2008·American Journal of Ophthalmology·Arthur M D BraakenburgAniki Rothova
Jun 1, 1949·Annals of the Rheumatic Diseases·H F West
Aug 30, 2008·Nature Reviews. Immunology·Eleanor N Fish
Jul 1, 2009·Arthritis and Rheumatism·Michael M WardMichael H Weisman
Jul 21, 2009·Clinical Rheumatology·Rohit Aggarwal, Anand N Malaviya
Aug 17, 2010·Rheumatology International·Hatice BodurUNKNOWN Türkiye Romatizma Araştırma ve Savaş Derneği [TRASD] (Turkish League Against Rheumatism) Ankylosing Spondylitis [AS] Study G
Sep 17, 2010·The Journal of Rheumatology·Pamir AtagunduzHaner Direskeneli
Jul 29, 2011·Clinical Rheumatology·Yousra Ibn YacoubNajia Hajjaj-Hassouni
Oct 13, 2011·Annals of the Rheumatic Diseases·Astrid van TubergenRobert Landewé
Nov 15, 2011·Arthritis and Rheumatism·Yao GongQing-Yu Zeng
Dec 29, 2011·Clinical Rheumatology·Hellen M S de CarvalhoUNKNOWN Brazilian Registry on Spondyloarthritis
Apr 3, 2012·International Journal of Rheumatic Diseases·Wen-Nan HuangGregory J Tsay
Apr 17, 2012·Annals of the Rheumatic Diseases·Rosaline van den BergDésirée van der Heijde
Oct 3, 2012·Handbook of Experimental Pharmacology·Vera Regitz-Zagrosek, Ute Seeland
Dec 13, 2012·Arthritis and Rheumatism·Joachim Sieper, Désirée van der Heijde
Dec 25, 2012·Annals of the Rheumatic Diseases·Irene E van der Horst-BruinsmaAndrew S Koenig

❮ Previous
Next ❯

Citations

May 27, 2020·Current Opinion in Rheumatology·Sebastián Ibáñez Vodnizza, Irene van der Horst-Bruinsma
Jul 10, 2020·PloS One·Hsin-Hua ChenYi-Hsing Chen
Jul 23, 2020·Immunology·Aniruddha Voruganti, Paul Bowness
May 30, 2020·Annals of the Rheumatic Diseases·Abhishek Arvind Zanwar
Oct 23, 2018·F1000Research·Leticia Garcia-MontoyaPaul Emery
Dec 6, 2019·Rheumatology International·Małgorzata TłustochowiczAndrzej Śliwczyński
Oct 1, 2020·Clinical Rheumatology·Diego Benavent, Victoria Navarro-Compán
May 6, 2020·Biology of Sex Differences·Sabra L Klein, Rosemary Morgan
Sep 22, 2020·World Journal of Clinical Cases·Yossy MachlufOrna Tal
Jul 10, 2020·Langenbeck's Archives of Surgery·Dedrick Kok Hong ChanDaryl Kai Ann Chia
Jan 7, 2021·Clinical Rheumatology·Walter P Maksymowych
Aug 2, 2020·Mayo Clinic Proceedings·Marina N MagreyJessica A Walsh
Oct 15, 2020·Rheumatology·Xabier MichelenaHelena Marzo-Ortega
Nov 3, 2020·Therapeutic Advances in Musculoskeletal Disease·Ho Yin ChungUNKNOWN Hong Kong Society of Rheumatology
Oct 15, 2020·Rheumatology·Matthew A BrownZhixiu Li
Oct 15, 2020·Rheumatology·Tamara RusmanIrene E van der Horst-Bruinsma
Mar 11, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bora NamTae-Hwan Kim
Mar 18, 2021·Journal of Comparative Effectiveness Research·Pedro Ricardo Kömel PimentaJuliana Alvares-Teodoro
Apr 8, 2021·American Journal of Ophthalmology·Nazife Şule Yaşar BilgeTimuçin Kasifoglu
May 12, 2021·Current Opinion in Rheumatology·Anand KumthekarMaureen Dubreuil
Dec 18, 2020·Arthritis Care & Research·Dax G RumseyUNKNOWN Childhood Arthritis and Rheumatology Research Alliance Registry Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
ESR

Software Mentioned

mSASSS
axSpA

Related Concepts

Related Feeds

Autoimmune Disease Therapy

In autoimmune diseases, the immune system responds and attacks self-antigens and damages or impairs the function of the tissues. The treatment for autoimmune diseases often involves immunosuppressive agents, but newer treatments are being investigated. Discover the latest research on autoimmune disease therapy here.