Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood

Developmental Psychobiology
B SchutováRomana Slamberová

Abstract

The aim of the present study was to compare the response to sub-chronic application of methamphetamine (MA) in adulthood in male and female rats prenatally exposed to the same drug. The spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to 5 mg/kg MA or saline (SAL) were tested in a Laboras apparatus (Metris B.V., Netherlands) for five consecutive days, 1 hr daily. MA 1 mg/kg or SAL were used as a challenge prior to testing. Our results showed that rats prenatally exposed to MA were more sensitive to sub-chronic administration of MA in adulthood than prenatally SAL-exposed rats. However, this sensitizing effect of prenatal MA exposure was manifested differently in males and females. In contrast, prenatal MA exposure decreased baseline locomotion in females. This study indicates that gender plays an important role in the sensitivity to MA during prenatal development and in adulthood.

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Citations

May 31, 2014·Prague Medical Report·Romana ŠlamberováJana Jurčovičová
Apr 14, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E MacúchováR Šlamberová
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Apr 30, 2015·Prague Medical Report·Markéta FialováRomana Šlamberová
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Jan 14, 2020·Physiological Research·L MihalčíkováR Šlamberová
Mar 7, 2021·International Journal of Molecular Sciences·Chrysostomos CharalambousMagdalena Sustkova-Fiserova
Mar 9, 2021·Frontiers in Behavioral Neuroscience·Ivana Petrikova-HrebickovaRomana Šlamberová
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Apr 9, 2021·Addiction·Fatima Anne PerezJu Lee Oei
Aug 3, 2021·Frontiers in Pharmacology·Jia-Hao LiXiao-Li Xie

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