Gender differences in bone mineral density in patients with sporadic primary hyperparathyroidism

Endocrinology, Diabetes & Metabolism
Danica VodopivecNancy Perrier

Abstract

Primary hyperparathyroidism reduces bone mineral density, which increases the risk of fracture. To investigate differences in bone mineral density and clinical characteristics after parathyroidectomy between men and women (premenopausal and postmenopausal) with sporadic primary hyperparathyroidism. This is a retrospective study of adult patients who underwent parathyroidectomy in a tertiary referral center from 1990 to 2013. A total of 1529 patients underwent parathyroidectomy during the study period; 80 patients met the inclusion criteria. Of these, 24 were men and 56 were women (10 premenopausal and 46 postmenopausal). Demographics, preoperative and postoperative biochemical analysis, preoperative and postoperative T-scores, preoperative Z-scores, preoperative and postoperative absolute bone mineral density values, and percentage change in bone mineral density from baseline to 12 ± 6 months after parathyroidectomy in the lumbar spine, femoral neck, total hip and distal one-third of the nondominant radius. Preoperative 24-hour urinary calcium levels were significantly higher in men than in women overall (P = 0.02) and postmenopausal women (P = 0.01). Men had significantly lower preoperative Z-scores than women overall, premeno...Continue Reading

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Citations

May 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Jessica PepeSerge Ferrari
Apr 26, 2020·International Journal of Molecular Sciences·Maria P YavropoulouPolyzois Makras
Feb 29, 2020·Visceral Medicine·Theresia WeberRainer Hummel

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BETA
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Vodopivec

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