Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals

Psychopharmacology
Helen C FoxR Sinha

Abstract

Extensive research suggests that gender may affect neuroendocrine and cardiovascular arousal mechanisms underlying biological responses to stress. To examine the impact of gender on response to stress and to drug-cue exposure in treatment-seeking cocaine abusers. Fifty recently abstinent cocaine dependent individuals (25F/25M), who were matched on cocaine use history, were exposed to a brief guided-imagery procedure that involved imagining a recent personal stressful situation, a personal drug-related situation and neutral-relaxing situation, one imagery per session, presented in random order. Subjective craving and anxiety, cardiovascular measures and plasma adrenocorticotrophic hormone (ACTH), cortisol and prolactin were assessed. Males showed significantly higher levels of ACTH, cortisol, and SBP, both at baseline and following all three imagery conditions. Females showed significantly higher basal heart rate and prolactin, although no gender differences were observed following imagery. No gender differences were seen in subjective anxiety or cocaine craving. Results indicate significant gender differences in baseline sensitivity and subsequent variations in hypothalamus-pituitary-adrenal (HPA) and cardiovascular response to...Continue Reading

References

Jun 1, 1978·Psychosomatic Medicine·M FrankenhaeuserC G Swahn
Jan 1, 1992·The American Journal of Drug and Alcohol Abuse·H R Kranzler, D J Wallington
Jul 1, 1992·Psychiatry Research·C J McDougleH D Kleber
Nov 1, 1992·Psychosomatic Medicine·C KirschbaumD Hellhammer
Mar 1, 1992·Journal of Studies on Alcohol·S K TeohJ Cochin
Aug 1, 1991·The American Journal of Psychiatry·B AdinoffM Linnoila
Nov 1, 1990·Biological Psychiatry·S K TeohB McAfee
Jun 1, 1995·European Journal of Endocrinology·J BornH L Fehm
Nov 1, 1993·Psychosomatic Medicine·M T AllenK A Matthews
Jun 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·L D DornG P Chrousos
Oct 10, 1998·Journal of Endocrinological Investigation·S LuisiA R Genazzani
Mar 18, 1999·Drug and Alcohol Dependence·S J RobbinsC P O'Brien
May 6, 1999·Psychopharmacology·R SinhaS O'Malley
Dec 22, 1999·The American Journal on Addictions·E F McCance-KatzB J Rounsaville
Feb 9, 2000·Psychopharmacology·W J Lynch, M E Carroll
Jun 1, 2000·Alcoholism, Clinical and Experimental Research·W R LovalloS J Nixon
Aug 15, 2000·Psychological Review·S E TaylorJ A Updegraff
Aug 31, 2000·The American Journal of Psychiatry·S G KornsteinM B Keller
Nov 1, 2000·Psychopharmacology·R SinhaS S O'Malley
Feb 13, 2001·Psychoneuroendocrinology·T E SeemanB McEwen
Jun 16, 2001·International Immunopharmacology·R W McMurray
Jun 22, 2001·The American Journal of Drug and Alcohol Abuse·I ElmanD R Gastfriend
Dec 26, 2001·Psychoneuroendocrinology·Nick E Goeders
Jan 18, 2002·Psychopharmacology·R Sinha
Mar 20, 2002·Addiction Biology·Ashwin A PatkarStephen P Weinstein
Jul 13, 2002·Annals of the New York Academy of Sciences·Candida SilvaJose Antonio P da Silva
Jul 30, 2002·The Journal of Clinical Psychiatry·Rajita Sinha, Bruce J Rounsaville
Sep 5, 2002·Biological Psychiatry·Laura R StroudElissa S Epel
Nov 2, 2002·The American Journal of Psychiatry·Frederic M QuitkinDonald F Klein
May 31, 2003·Stress : the International Journal on the Biology of Stress·T TraustadóttirK S Matt
Jun 12, 2003·Steroids·Shintarou YoshimuraRyohei Okamoto
Jul 2, 2003·Journal of Neuroendocrinology·Carmine M Pariante
Jul 4, 2003·The Clinical Journal of Pain·Christiane ZimmerStefan Lautenbacher
Apr 10, 2004·Neuroreport·Karen A TuckerThomas R Kosten
Jun 30, 2004·Journal of Substance Abuse Treatment·Robert C SterlingEdward Gottheil

❮ Previous
Next ❯

Citations

May 2, 2007·Experimental and Clinical Psychopharmacology·C W LejuezJohn J Curtin
Dec 3, 2008·Behavioral Neuroscience·N DevidzeM J Kreek
Oct 2, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Helen C FoxRajita Sinha
Mar 15, 2013·Brain : a Journal of Neurology·Xi LuoChiang-Shan R Li
May 28, 2011·Reviews in the Neurosciences·Adam StewartAllan V Kalueff
May 24, 2014·Journal of Endocrinological Investigation·L ManettiA Ambrogio
Apr 9, 2014·Psychopharmacology·Megan M Moran-Santa MariaKathleen T Brady
Jun 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Helen C FoxRajita Sinha
Jan 8, 2011·Addictive Behaviors·Bradley N CollinsEugene Komaroff
Oct 12, 2010·Physiology & Behavior·Raissa Menéndez-Delmestre, Annabell C Segarra
Dec 23, 2009·Hormones and Behavior·Annabell C SegarraYvonne M Torres-Diaz
Dec 17, 2009·Behavioural Brain Research·Jonathan CachatAllan V Kalueff
Sep 12, 2009·Psychoneuroendocrinology·Liana FattoreWalter Fratta
May 24, 2008·Physiology & Behavior·Marcos A López PatiñoIrina V Zhdanova
Sep 29, 2007·Drug and Alcohol Dependence·Scott M HymanRajita Sinha
Feb 20, 2007·Pharmacology, Biochemistry, and Behavior·Jiang YuLin Lu
Mar 3, 2015·Drug and Alcohol Dependence·Leslie H Lundahl, Mark K Greenwald
Aug 8, 2014·Frontiers in Psychiatry·Marijn LijffijtAlan C Swann
Jan 8, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Helen C FoxRajita Sinha
Dec 24, 2019·The International Journal of Neuropsychopharmacology·Krista L Connelly, Ellen M Unterwald
Nov 22, 2016·Journal of Neuroscience Research·Aimee L McRae-ClarkKathleen T Brady
Aug 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Florence MorissetteDidier Jutras-Aswad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.