Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Ying WangG Nestadt

Abstract

Several clinical and genetic studies have reported gender differences in obsessive-compulsive disorder (OCD). Previously, we conducted a linkage genome scan using multipoint allele-sharing methods to test for linkage in 219 families participating in the OCD Collaborative Genetics Study. When these families were stratified by proband's gender, suggestive linkage to chromosome 11p15 at marker D11S2362 (KAC(all) = 2.92, P = 0.00012) was detected in families with male probands, but not in the ones with female probands. We have since conducted fine mapping with a denser microsatellite marker panel in the region of 11p15, and detected a significant linkage signal at D11S4146 (KAC(all) = 5.08, P < 0.00001) in the families of male probands. Subsequently, 632 SNPs were genotyped spanning a 4.0 Mb region of the 1 LOD unit interval surrounding the linkage peak in the original families and an additional 165 families. Six SNPs were associated with OCD (P < 0.001): two SNPs were identified when all the families were included, and four SNPs only in male proband families. No SNP showed significant association with the OCD phenotype only in the families with a female proband. The results suggest a possible gender effect in the etiology of OCD.

References

Jul 9, 1992·Nature·H H Van TolV Jovanovic
Sep 1, 1992·The American Journal of Psychiatry·H L LeonardJ L Rapoport
Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Sep 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·M A RiddleD J Cohen
May 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·M C LenaneJ L Rapoport
Jan 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jan 1, 1995·The American Journal of Psychiatry·D L PaulsJ F Leckman
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox
Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Jul 29, 1998·The Journal of Nervous and Mental Disease·G NestadtW W Eaton
Nov 4, 1998·Psychiatric Genetics·E A BillettJ L Kennedy
Mar 2, 1999·American Journal of Medical Genetics·M C CavalliniE Smeraldi
Nov 27, 1999·Psychological Medicine·R BarnettC Pantelis
Dec 3, 1999·American Journal of Medical Genetics·J P Alsobrook IID L Pauls
Apr 18, 2000·Archives of General Psychiatry·G NestadtR Hoehn-Saric
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird
Oct 17, 2001·The International Journal of Neuropsychopharmacology·B CamarenaH Nicolini
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Dec 6, 2001·Nature Reviews. Genetics·S E Folstein, B Rosen-Sheidley
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuan-Chun DingRobert K Moyzis
Jan 16, 2002·American Journal of Human Genetics·Julie A DouglasMichael Boehnke
Feb 13, 2002·American Journal of Medical Genetics·John P AlsobrookDavid L Pauls
Jul 13, 2002·American Journal of Medical Genetics·Gregory L HannaEdwin H Cook
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bruno MilletMarie-Odile Krebs
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sîan M J HemmingsDan J Stein
Nov 19, 2003·Journal of Consulting and Clinical Psychology·Jonathan S AbramowitzJami M Furr
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
May 3, 2005·The American Journal of Psychiatry·Deborah E LynnSusan L Smalley
Oct 7, 2005·Pharmacogenomics·Frank J Steemers, Kevin L Gunderson
Mar 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jack F SamuelsGerald Nestadt

❮ Previous
Next ❯

Citations

Jul 29, 2009·Current Psychiatry Reports·Jack F Samuels
Oct 13, 2009·Psychiatry Research·Humberto NicoliniJames L Kennedy
Dec 3, 2008·Psychological Medicine·G NestadtK Bandeen Roche
Oct 17, 2012·Psychiatry and Clinical Neurosciences·Gayatri SarafY C Janardhan Reddy
May 20, 2009·Annals of General Psychiatry·Michele FornaroPantaleo Fornaro
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dennis L MurphyKiara R Timpano
Jul 18, 2012·Child and Adolescent Psychiatric Clinics of North America·Dara J SakolskyErika L Nurmi
May 29, 2012·Biological Psychiatry·Carol A MathewsGregory L Hanna
Feb 18, 2010·The Psychiatric Clinics of North America·Gerald NestadtJack F Samuels
Oct 3, 2009·Depression and Anxiety·Joan TabernerDavid Mataix-Cols
Jul 21, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Marco A Grados
May 23, 2014·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Emilio L StreckJoão Quevedo
May 27, 2010·Brain Imaging and Behavior·Stephen CorreiaBenjamin D Greenberg
Aug 2, 2017·Molecular Psychiatry·UNKNOWN International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Asso
Jun 30, 2021·Nature Neuroscience·Mathew HalvorsenDavid B Goldstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.