Gender differences in hemostatic and inflammatory factors in patients with acute coronary syndromes: a pilot study

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
A SiennickaZ Kornacewicz-Jach

Abstract

Many studies have shown gender differences in the progress of acute coronary syndromes (ACS). These differences include, amongst others, processes involved in hemostasis and inflammation, and in the present study we put forward the hypothesis that these are the primary cause of other differences. The study included 66 ACS patients (27 women and 39 men) aged 43 - 83 years, 23 with non-ST-elevation myocardial infarction (NSTEMI) and 43 with ST-elevation myocardial infarction (STEMI). Blood samples were taken on day 3 (NSTEMI) or day 5 (STEMI) after hospitalization, and fibrinogen, D-dimers, von Willebrand factor, C-reactive protein and interleukin-6 levels measured. Men, compared to women, had significantly higher levels of fibrinogen (STEMI: P = 0.028; NSTEMI: P = 0.008), C-reactive protein (STEMI: P <0.0001; NSTEMI: P = 0.004) and interleukin-6 with STEMI (P = 0.015), but a lower D-dimer concentration with NSTEMI (P = 0.042). In women fibrinogen concentration was significantly higher with STEMI compared to NSTEMI (P = 0.052). Significant correlations were found between hemostatic and proinflammatory factors, especially in men, regardless of ACS type. In addition, correlations between fibrinogen and D-dimers were found: negative...Continue Reading

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