Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity.

Psychoneuroendocrinology
Magdalena UhartGary S Wand

Abstract

The present study was designed to determine whether there are gender differences in hormonal response patterns to HPA axis activation. To this end, two methods of activating the HPA axis were employed: a standardized psychological stress test and a pharmacological challenge. Healthy subjects (mean age 23.4 years, SD 7.0 years) completed a naloxone challenge and/or the modified Trier Social Stress Test (TSST). For the naloxone challenge, two baseline blood samples were obtained. Placebo was then administered (0 min), followed by increasing doses of intravenous naloxone (50, 100, 200 and 400 microg/kg) at 30-min intervals. Post-placebo blood samples were collected at 15-min intervals for 180 min. The TSST consisted of 5 min of public speaking followed by 5 min of mental arithmetic exercises. Three baseline and five post-TSST blood samples were drawn. Eighty subjects (53 male, 27 female) underwent the TSST. Following the psychological stressor, adrenocorticotropin (ACTH) and cortisol responses were significantly greater in male subjects compared to female subjects (z=-2.34, p=0.019 and z=-2.12, p=0.034, respectively). Seventy-two subjects (52 male, 20 female) underwent HPA axis activation induced by naloxone. In contrast to the TS...Continue Reading

Citations

Nov 19, 2013·Neuroscience and Biobehavioral Reviews·Andrew P AllenGerard Clarke
Feb 1, 2014·Psychopharmacology·Duncan SinclairCynthia Shannon Weickert
Apr 8, 2014·Animal : an International Journal of Animal Bioscience·E van LierA Meikle
May 2, 2007·Experimental and Clinical Psychopharmacology·Scott M HymanRajita Sinha
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M KeenanJohannes D Veldhuis
Sep 17, 2009·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisSteven M Pincus
Feb 26, 2010·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Misaki N NatsuakiCarolyn Zahn-Waxler
May 11, 2010·Biological Research for Nursing·Norah S SimpsonDavid F Dinges
Nov 16, 2007·Pharmacogenetics and Genomics·Carlos A Hernandez-AvilaHenry R Kranzler
Apr 12, 2008·Pituitary·Alberto Giacinto AmbrogioFrancesco Cavagnini
Jul 9, 2008·Development and Psychopathology·Stephanie H M van Goozen, Graeme Fairchild
Jul 16, 2011·Development and Psychopathology·Robert-Paul JusterSonia J Lupien
Mar 24, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Gareth Edward Hagger-JohnsonWarren G Holroyd
May 25, 2010·Current Opinion in Psychiatry·Maria Luisa Figueira, Sílvia Ouakinin
Jan 29, 2010·Stress : the International Journal on the Biology of Stress·Brigitte M Kudielka, Stefan Wüst
Nov 3, 2011·Stress : the International Journal on the Biology of Stress·J Tortosa-Martínez, A Clow
Jul 9, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Ase Marie HansenRoger Persson
Jul 4, 2012·The American Journal of Drug and Alcohol Abuse·Rodrigo Grassi-OliveiraElisa Brietzke
Jul 20, 2010·NeuroImage·Joseph M Andreano, Larry Cahill
Jan 26, 2010·Forensic Science International : Synergy·R GowG Koren
Nov 2, 2015·Psychoneuroendocrinology·Elias K SpanakisSherita Hill Golden
Oct 20, 2009·Psychoneuroendocrinology·Daniel J O RocheAndrea C King
Apr 28, 2009·Psychiatry Research·Michel LucasBruce J Holub
May 5, 2009·Journal of Experimental Child Psychology·Nestor L Lopez-DuranDelia M Vazquez
Mar 3, 2009·Psychoneuroendocrinology·Stefan WüstMarcella Rietschel
Mar 11, 2009·Brain, Behavior, and Immunity·Beth D Darnall, Edward C Suarez
Nov 13, 2007·Physiology & Behavior·Paula Ayako TibaDeborah Suchecki
Oct 24, 2007·Peptides·Richard J Bodnar

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