Gender differences in pain and secondary hyperalgesia after heat/capsaicin sensitization in healthy volunteers

The Journal of Pain : Official Journal of the American Pain Society
Magnus Thorsten Jensen, Karin Lottrup Petersen

Abstract

In most published studies women are more sensitive to experimental pain than men. Enhanced central pain processing in women has been suggested, but psychosocial factors might also have affected the findings. Data from five completed healthy volunteer studies were analyzed to investigate gender differences in development of secondary hyperalgesia. Cutaneous hyperalgesia was induced with the heat/capsaicin sensitization model. Outcome measures were areas of secondary hyperalgesia to brush and von Frey hair stimulation after heat and capsaicin sensitization, rating of pain during heat/capsaicin sensitization, and heat pain detection thresholds. There was a trend toward smaller areas of secondary hyperalgesia in women. After adjusting for estimated gender differences in forearm surface area, areas to brush but not von Frey hair stimulation after capsaicin sensitization were larger in women. Peak pain, but not total pain, during prolonged noxious thermal stimulation was higher in women. There was no gender difference in pain ratings during capsaicin sensitization or in heat pain detection thresholds. The results provided only limited support to the hypothesis that gender differences in clinical pain syndromes can be explained by enh...Continue Reading

References

Mar 1, 1991·Pain·J S FeineG H Duncan
Aug 26, 1998·Journal of Pain and Symptom Management·M LiuG J Bennett
Mar 31, 1999·The Behavioral and Brain Sciences·K J Berkley
Jun 25, 1999·Neuroreport·K L Petersen, M C Rowbotham
May 29, 2002·Pain·Eleni Sarlani, Joel D Greenspan
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Karin L PetersenMichael C Rowbotham
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Jesper DirksJørgen B Dahl
Mar 26, 2004·The Journal of Pain : Official Journal of the American Pain Society·Michael E RobinsonDonald D Price
Jun 23, 2004·European Journal of Pain : EJP·Michael E RobinsonJennifer L Brown

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Citations

Oct 12, 2012·Journal of Pain Research·Pernille RavnMads U Werner
Nov 24, 2011·Pain Research and Treatment·Yannick Tousignant-Laflamme, Serge Marchand
Jul 30, 2014·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Jeffrey S OrringerDana L Sachs
Nov 26, 2013·The Journal of Pain : Official Journal of the American Pain Society·Waylan Wong, Mark S Wallace
May 5, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger B FillingimJoseph L Riley
Apr 17, 2007·The Journal of Pain : Official Journal of the American Pain Society·Christian GeberFrank Birklein
Sep 27, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·A I M van LaarhovenA W M Evers
Apr 21, 2009·Brain Research·Nicole M E CarmichaelJonathan O Dostrovsky
Jul 26, 2008·Brain Research·Yannick Tousignant-LaflammeSerge Marchand
Jul 14, 2009·Pain·Yannick Tousignant-Laflamme, Serge Marchand
Jul 28, 2009·Pain·Javeria A Hashmi, Karen D Davis
Jul 31, 2013·Pain·Javeria A Hashmi, Karen D Davis
May 20, 2014·Journal of Chromatographic Science·Hussein G DaoodLajos Helyes
Jun 22, 2016·Neuroscience·Heather L RossiAna Recober
Dec 21, 2006·The American Journal of Gastroenterology·Ann Ouyang, Helena F Wrzos
Oct 22, 2011·Expert Review of Neurotherapeutics·Lars Arendt-Nielsen, Hans Christian Hoeck
Mar 14, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Assunta GasparinWolnei Caumo
May 31, 2020·International Journal of Molecular Sciences·Karina Angélica Méndez-ReséndizSara Luz Morales-Lázaro
Aug 27, 2015·Current Opinion in Anaesthesiology·Manuel P Pereira, Esther Pogatzki-Zahn
Jan 12, 2019·Brain Structure & Function·Morten Sejer HansenMohammad Sohail Asghar
Dec 7, 2017·Journal of Molecular Neuroscience : MN·Xiaofeng BaiQing Zhou
May 20, 2020·Journal of Pain Research·Larissa J StrathBurel R Goodin
Aug 30, 2018·Frontiers in Molecular Biosciences·Maite Artero-MoralesAntonio Ferrer-Montiel
Oct 17, 2020·Journal of Pain Research·Ines DaguetGuillaume Leonard
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea

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