Gender differences in seizure recurrence and antiepileptic drug polytherapy predicting health-related quality of life of persons 1 year after diagnosis of epilepsy.

Epilepsy & Behavior : E&B
Sang-Ahm LeeOk-Joon Kim

Abstract

The aim of this study was to determine whether gender influences the prediction of health-related quality of life (HRQoL) in persons with newly diagnosed epilepsy (NDE). This was a 1-year longitudinal study. Persons with NDE were assessed with the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), the Hospital Anxiety Depression Scale (HADS), the Stigma Scale, and the Rosenberg Self-esteem Scale. An analysis of covariance (ANCOVA) with interaction terms was used. Among 134 adults with NDE, there were no gender differences in the scores of the QOLIE-31 and its subscales. A multivariate linear regression analysis showed that the HADS-anxiety scores at diagnosis (p = 0.005) and seizure recurrence after diagnosis (p = 0.050) negatively predicted QOLIE-31 scores in persons with NDE. There were significant effects of the gender interaction with seizure recurrence (F = 8.745, p = 0.004, partial eta2 = 0.066) and antiepileptic drug (AED) polytherapy (F = 6.320, p = 0.013, partial eta2 = 0.049) in the adjusted model. Specifically, seizure recurrence negatively predicted the QOLIE-31 scores only in men. By contrast, AED polytherapy negatively predicted the QOLIE-31 scores only in women. There are gender differences in certain epilepsy-...Continue Reading

References

Mar 1, 1997·Epilepsia·G A BakerD Monnet
Dec 5, 2003·Epilepsy & Behavior : E&B·Frank GilliamYvette Sheline
Mar 20, 2013·Epilepsy & Behavior : E&B·Arthur C GrantLuba Nakhutina
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe
May 20, 2016·Epilepsy & Behavior : E&B·Aleksandra BalaAndrzej Marchel
Nov 14, 2016·Epilepsy & Behavior : E&B·Altaf SaadiFarrah J Mateen

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