PMID: 11905526Mar 22, 2002Paper

Gender differences in serum markers of bone resorption in healthy subjects and patients with disorders affecting bone

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Salvatore MinisolaElisabetta Romagnoli

Abstract

To assess how two different serum markers of bone resorption may reflect changes in bone turnover, we compared age- and sex-related changes in serum C-terminal telopeptide of type I collagen (betaCTx) and tartrate-resistant acid phosphatase activity (TRAP) in 136 healthy men and 184 normal women. Serum levels of the two markers were also assessed in several groups of patients of both sexes presenting with the most common metabolic and endocrine bone diseases: established osteoporosis (n = 77), primary hyperparathyroidism (n = 44), glucocorticoid excess (n = 17), chronic renal failure (n = 39), active Paget's disease of bone (n = 5), humoral hypercalcemia of malignancy (n = 3), osteomalacia (n = 3), hyperthyroidism (n = 10), post-surgical hypoparathyroidism (n = 10), acromegaly (active disease, n = 8) and Cushing's syndrome (n = 10). In men the regression of betaCTx with age showed an initial decrease in bone resorption followed by an increase thereafter, starting from the sixth decade of life. No age-related change in serum TRAP activity was observed. In women, by contrast, a slight but significant linear correlation of both serum betaCTx and TRAP with age (r = 0.223, p<0.003 and r = 0.333, p<0.0001, respectively) was found, th...Continue Reading

Citations

Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Olafur S IndridasonGunnar Sigurdsson
Jun 15, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SzulcP D Delmas
Jun 27, 2003·Transplantation Proceedings·J MałyszkoM Myśliwiec
Oct 23, 2013·European Journal of Endocrinology·Sara PiemonteSalvatore Minisola
Aug 28, 2013·Advances in Chronic Kidney Disease·L Tammy Ho, Stuart M Sprague
Jul 3, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·José M OlmosJesús González-Macías
Dec 15, 2015·Bone Research·Ditte Mh MerrildKent Søe
May 26, 2004·Clinics in Laboratory Medicine·Catherine A Hammett-Stabler
Apr 18, 2015·Annales d'endocrinologie·Elizabeth L Monis, Michael Mannstadt
Oct 19, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ani UralDeepak Vashishth
Apr 18, 2008·Experimental and Molecular Pathology·Wei LiuManling Ma
Jul 27, 2007·Renal Failure·Jolanta MałyszkoMichał Myśliwiec
Jun 21, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SzulcUNKNOWN National Bone Health Alliance Bone Turnover Marker Project
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Nov 20, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Dedi CandraDonald E Paglia
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Jul 9, 2020·Bone Research·Anaïs Marie Julie MøllerKent Søe
Oct 22, 2019·Therapeutic Advances in Musculoskeletal Disease·Salvatore MinisolaJessica Pepe
Apr 27, 2020·Journal of Endocrinological Investigation·P Szulc
Jul 2, 2021·Bone Research·Anaïs Marie Julie MøllerKent Søe
Jul 12, 2021·Trends in Endocrinology and Metabolism : TEM·Francesca SalamannaMilena Fini

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