Gender differences in survival after lung transplant: implications for cancer etiology

Transplantation
Michael CreelEmanuela Taioli

Abstract

Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer than males: 50.75+/-55.41 months versus 40.64+/-47.60 months, respectively. Males had a risk of dying during the follow up that was 1.18 (95% CI 1.01-1.40) relative to females, after adjusting for ethnicity, age, smoking status, diagnosis and donor characteristics. Females who had at least one full term pregnancy during their life had better survival rates than females who had no full term pregnancies. Our results of a better survival after lung transplant in females, and among them in those who had at least a full term pregnancy support the hypothesis of a hormonal contribution to survival and of the development of immunotolerance after pregnancy. This model could be useful for understanding the role of immunity in cancer development.

References

Jan 3, 2001·Medical Hypotheses·D T Janerich
Jan 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hirohisa HaradaMatthew B Grisham
Feb 9, 2005·Journal of Molecular and Cellular Cardiology·Scott A GabelElizabeth Murphy
Feb 24, 2005·Brain Research·Kirsty B GordonHilary V O Carswell
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elbert P TrulockMarshall I Hertz
Sep 27, 2005·Journal of Women's Health·Hilary Sanfey
May 30, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·UNKNOWN International Society of Heart and Lung Transplantation RegistryShaf Keshavjee
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn L TerryDaniel W Cramer

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Citations

Jul 23, 2013·The Annals of Thoracic Surgery·Anthony W CastleberryMatthew G Hartwig
May 4, 2010·Gender Medicine·Joy M Jacobs-LawsonSusanne Arnold

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