Gender differences in the association between melatonin secretion and diabetes in elderly: The HEIJO-KYO cohort

Clinical Endocrinology
Kenji ObayashiKeigo Saeki

Abstract

Reportedly, melatonin protects the pancreatic islets and decreases insulin resistance; thus, it may contribute to preventing diabetes. Epidemiological data suggested that lower melatonin secretion is associated with higher incidence of diabetes in female nurses. Such associations are unknown in the general population. We evaluated the association between melatonin secretion and diabetes in a general population, including both genders. Cross-sectional study. A total of 1096 community-based elderly males (n = 519) and females (n = 577) (mean age, 71.8 years) were enrolled. Overnight urinary 6-sulfatoxymelatonin excretion (UME) and diabetes prevalence were measured. The median UME was 6.7 μg (interquartile range, 4.0-10.5); the prevalence of diabetes was 17.5% in males and 10.7% in females. The prevalence of diabetes decreased with increasing UME quartiles among males (P for trend = 0.009) but not among females (P for trend = 0.96). In a multivariable logistic regression analysis adjusting for potential confounding factors, such as age, smoking and drinking habits, economic status, caloric intake, and physical activity, the odds ratio (OR) for diabetes was significantly lower in the highest UME quartile group compared with the low...Continue Reading

References

Nov 1, 1994·Diabetes·G S Hotamisligil, B M Spiegelman
Jan 16, 1997·The New England Journal of Medicine·A Brzezinski
Feb 19, 1998·Journal of Pineal Research·J J BaskettT A Antunovich
Apr 2, 1999·Psychoneuroendocrinology·L WetterbergA Yuwiler
Oct 24, 2001·Journal of Biological Rhythms·M DumontJ Paquet
Oct 3, 2003·Journal of Pineal Research·Shigeru NishidaShigeki Nakagawa
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter
Jul 8, 2005·Scandinavian Journal of Work, Environment & Health·Yuko MorikawaKoji Nogawa
Jan 16, 2008·Journal of Pineal Research·Reshma D RamracheyaShanta J Persaud
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frank A J L ScheerSteven A Shea
Apr 8, 2010·The Journal of Clinical Endocrinology and Metabolism·Esther DongaJohannes A Romijn
Aug 4, 2010·Journal of Biological Rhythms·Sean W CainJeanne F Duffy
Sep 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Kenji ObayashiNorio Kurumatani
Apr 4, 2013·JAMA : the Journal of the American Medical Association·Ciaran J McMullanJohn P Forman
Jul 3, 2013·American Journal of Epidemiology·Ciaran J McMullanJohn P Forman
Mar 25, 2014·Journal of Pineal Research·J Cipolla-NetoR J Reiter
Apr 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Philippe A HalbanGordon C Weir
Jul 2, 2014·Journal of Pineal Research·Bruno G TeodoroElaine Vieira
Jul 18, 2014·Occupational and Environmental Medicine·Yong GanZuxun Lu
Sep 17, 2014·Journal of Epidemiology·Kenji ObayashiNorio Kurumatani

❮ Previous
Next ❯

Citations

Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yixin CuiYu Sun
Aug 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arezoo Fathalizadeh AlamdariSarvin Sanaie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.