Gender differences in the effects of cathinone and the interaction with caffeine on temperature and locomotor activity in the rat

European Journal of Pharmacology
Hadeel A Alsufyani, James R Docherty

Abstract

We have investigated gender differences in the effects of cathinone and the interaction with caffeine on temperature and movement activity in Wistar rats. Telemetry probes were implanted in rats under isoflurane anaesthesia, and 7 days later, temperature and activity were recorded in conscious unrestrained animals. Caffeine (10mg/lkg) or vehicle, and 30min later, cathinone (5mg/kg) or vehicle, were injected subcutaneously. Cathinone produced significant and marked increases in activity, and the response to cathinone was significantly greater in female animals. The combination of caffeine and cathinone causes a short lived potentiation followed by a prolonged inhibition of the activity response to cathinone. Cathinone alone had minor effects on temperature. However, the combination of caffeine and cathinone produced a significant acute rise in temperature only in male rats in the 90min after cathinone injection. Hence, cathinone caused greater increases in activity in female than in male rats. Secondly, caffeine produced an initial potentiation followed by a prolonged inhibition of the activity response to cathinone. Thirdly, cathinone in combination with caffeine significantly raised temperature acutely in male but not female r...Continue Reading

Citations

Aug 24, 2019·British Journal of Pharmacology·James R DochertyAmrita Ahluwalia
Mar 27, 2019·Psychopharmacology·Ana Belen Lopez-Rodriguez, Maria-Paz Viveros
Sep 10, 2020·Brain Sciences·Liana FattoreMaria Paola Castelli
Nov 18, 2020·Journal of Analytical Toxicology·Yang WangGengli Duan
Apr 1, 2021·British Journal of Pharmacology·James R Docherty, Hadeel A Alsufyani
Aug 17, 2021·Journal of Clinical Pharmacology·James R Docherty, Hadeel A Alsufyani

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