Gender differences in the relationship between the risperidone metabolism and the plasma prolactin levels in psychiatric patients

Progress in Neuro-psychopharmacology & Biological Psychiatry
Yutaro SuzukiToshiyuki Someya

Abstract

Risperidone (RIS) has the highest propensity to elevate plasma prolactin (PRL) levels. While the active metabolite 9-hydroxy-risperidone (9-OH-RIS) plays a predominant role in the efficacy and side effects of RIS, the mechanistic details are still poorly understood. The present study evaluated the gender differences in the relationship between plasma levels of RIS or 9-OH-RIS and PRL. Twenty-one male and 19 female subjects treated with RIS were enrolled in the present series. All patients had been receiving RIS for at least 4 weeks at an average dosage of 4.7 mg/day. Plasma RIS, 9-OH-RIS and PRL levels were measured. In the male patients, there was no correlation between the RIS dosage and plasma PRL levels, between plasma RIS levels and PRL levels, or between the plasma 9-OH-RIS levels and PRL levels. In the female patients, there was a significant positive correlation between the plasma 9-OH-RIS levels and PRL levels (rs=0.456, p=0.049). There was a trend toward a significant positive correlation between the RIS dosage and plasma PRL levels. There was no correlation between the plasma RIS levels and PRL levels. 9-OH-RIS is considered to play a more important role in PRL elevation than RIS, and a gender difference exists in th...Continue Reading

References

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Feb 10, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bun-Hee Lee, Yong-Ku Kim
Jul 11, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kazushi SawamuraToshiyuki Someya
Aug 16, 2008·Journal of Psychopharmacology·Peter Fitzgerald, Timothy G Dinan

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Citations

Jul 2, 2015·Clinical Pharmacokinetics·Frederik VandenbergheChin B Eap
Jun 30, 2012·Human Psychopharmacology·Yutaro SuzukiToshiyuki Someya
Feb 18, 2016·Basic & Clinical Pharmacology & Toxicology·Nattawat NgamsamutChonlaphat Sukasem
May 7, 2020·Frontiers in Endocrinology·Samantha Alvarez-HerreraLenin Pavón

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