Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I.

The Journal of Endocrinology
Yongmei WangDaniel D Bikle

Abstract

Parathyroid hormone (PTH) exerts both catabolic and anabolic actions on bone. Studies on the skeletal effects of PTH have seldom considered the effects of gender. Our study was designed to determine whether the response of mouse bone to PTH differed according to sex. As a first step, we analyzed gender differences with respect to bone mass and structural properties of 4 month old PTH treated (80 microg/kg per day for 2 weeks) male and female CD-1 mice. PTH significantly increased fat free weight/body weight, periosteal bone formation rate, mineral apposition rate, and endosteal single labeling surface, while significantly decreasing medullary area in male mice compared with vehicle treated controls, but induced no significant changes in female mice. We then analyzed the gender differences in bone marrow stromal cells (BMSC) isolated from 4 month old male and female CD-1 mice following treatment with PTH (80 microg/kg per day for 2 weeks). PTH significantly increased the osteogenic colony number and the alkaline phosphatase (ALP) activity (ALP/cell) by day 14 in cultures of BMSCs from male and female mice. PTH also increased the mRNA level of receptor activator of nuclear factor kappaB ligand in the bone tissue (marrow removed) ...Continue Reading

Citations

Jul 5, 2007·Histochemistry and Cell Biology·Lindsay M Martin, Laura R McCabe
Apr 25, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wesley G BeamerClifford J Rosen
Jul 4, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karin A CorsiJohnny Huard
Jun 2, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yongmei WangDaniel D Bikle
Feb 6, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bernard RocheMarie-Hélène Lafage-Proust
Mar 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yongmei WangDaniel D Bikle
Dec 17, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Muriel BabeyDaniel D Bikle
Mar 31, 2015·Clinical Orthopaedics and Related Research·Weiwei DaiWei Yao
May 29, 2009·American Journal of Physiology. Renal Physiology·Geun-Shik LeeEui-Bae Jeung
Sep 16, 2006·Endocrinology·Regina IrwinLaura R McCabe
Feb 13, 2016·The Journal of Biological Chemistry·Candice G T TahimicDaniel D Bikle
Oct 18, 2019·Journal of the Endocrine Society·Scott MunsonDaniel D Bikle
Jun 15, 2007·Current Opinion in Nephrology and Hypertension

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