Abstract
Over the past decades, incidence trends of colorectal cancer are sharply increased in Singapore. In this population-based study we describe changes in colorectal cancer incidence in Singapore and explore the reasons behind these changes through age-period cohort (APC) modeling. We included all 22,609 colorectal cancer cases reported to the Singapore Cancer Registry between 1968 and 2002. Poisson regression, using age-period (AP) and age-cohort (AC) models was used to determine the effects of age at diagnosis, calendar period, and birth cohort. Male colorectal cancer rates between 1968 and 2002 from 20 to 40 per 100,000 person years. The increase was sharpest among older men, for whom there was a significant AC effect. Female colorectal cancer rates increased until 1992 (from 16 to 29 per 100,000 person years) and stabilized afterward. For women under 65 years, we observed a significant AP effect, corresponding to a sudden rise in colorectal cancer incidence around 1978. This study demonstrates important gender differences in colorectal cancer incidence in Singapore, with increasing rates among men, and stabilized rates in women. The increase in men is mainly attributable to an incidence increase in the oldest age groups, probab...Continue Reading
References
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·H P LeeN E Day
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·H P LeeK Shanmugaratnam
Jun 1, 1987·Statistics in Medicine·D Clayton, E Schifflers
Feb 1, 1996·International Journal of Epidemiology·A SeowH P Lee
Aug 1, 1996·Social Science & Medicine·D G UitenbroekN Festchieva
Apr 29, 1999·Social Science & Medicine·M Denton, V Walters
Jun 22, 1999·Cancer·J HuangH P Lee
Nov 19, 2002·Cancer·Adeline SeowTar-Choon Aw
Nov 11, 2003·The Journal of Nutrition·Lynn B Bailey
Apr 15, 2004·Social Science & Medicine·Margaret DentonVivienne Walters
May 20, 2004·British Journal of Cancer·W-P KohM C Yu
Jul 3, 2004·Nutrition and Cancer·Patricia M HeaveyIan R Rowland
Jul 22, 2004·Journal of the National Cancer Institute·Donald E Henson, Jorge Albores-Saavedra
Aug 24, 2004·Oncogene·Donald M Parkin
Jul 14, 2005·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·A FrancoJ A Solís Herruzo
Jul 13, 2006·Cancer·Jeannette Jackson-ThompsonCarol Friedman
Aug 21, 2007·Preventive Medicine·E S T NgK H Phua
Citations
Nov 1, 2011·International Journal of Colorectal Disease·Tzu-An ChenJorng-Tzong Horng
Jan 11, 2013·Japanese Journal of Clinical Oncology·Melissa C C Teo, Khee Chee Soo
Mar 1, 2012·Journal of Clinical Psychopharmacology·Kevin Yi-Lwern YapUNKNOWN Onco-Informatics Group
Jan 16, 2010·Journal of Gastroenterology and Hepatology·Yuk Kei YeeBenjamin C Y Wong
Dec 17, 2009·Journal of Gastroenterology and Hepatology·Yuk Kei YeeBenjamin C Y Wong
Jan 19, 2011·BMC Cancer·Meei-Shyuan LeeYi-Chen Huang
Dec 9, 2008·Journal of Neurosurgery·Courtney S McGuirePaul G Fisher
Mar 8, 2013·World Journal of Gastroenterology : WJG·Aesun ShinYoung-Joo Won
May 31, 2014·World Journal of Gastroenterology : WJG·Faraz BishehsariRenato Mariani-Costantini
Apr 20, 2010·Cancer Epidemiology·Jeffrey D WesslerStephen W Duffy
Jun 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiangjun FanZhiwei Wang
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Farid ZayeriAnita Mansouri
Nov 21, 2008·Cancer Science·Hirokazu TakahashiAtsushi Nakajima
Aug 5, 2011·Cancer·Andrew O OdegaardJian Min Yuan
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Azadeh SafaeeMohammad Reza Zali
Jun 1, 2012·Toxicological Research·Kevin Yi-Lwern YapAlexandre Chan
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Alexey S ZhivotovskiyElena B Brusina
Apr 26, 2012·World Journal of Gastrointestinal Oncology·Mohamad Amin Pourhoseingholi
Dec 11, 2008·Cancer Causes & Control : CCC·William B Goggins, Grace Wong
Oct 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Goh, A Vathsala
Jun 13, 2015·SpringerPlus·Klaus Heese
Sep 1, 2009·Yonsei Medical Journal·Patrick Tan
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Marzieh Rohani-RasafMohsen Asadi-Lari
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Edris AbdifardMohammad Heidari
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bello Arkilla MagajiChee Wei Law
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Yonho JeeAesun Shin
Feb 13, 2018·Oncotarget·Haochang HuShiwei Duan
Jan 1, 2013·Cancer Prevention Research·Andrew O OdegaardJian-Min Yuan
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ahmedin JemalElizabeth M Ward