Gender dimorphism of body mass perception and regulation in mice

The Journal of Experimental Biology
Petra WiedmerSusanne Klaus

Abstract

According to the set-point theory of body mass, changes in body mass are perceived by the body, leading to activation of compensatory feedback mechanisms, which in turn restores the set-point body mass. However, this theory is still under debate. To test if mass per se might be sensed and regulated, we implanted loads corresponding to 10% (HI) or 2% (LO, control) of body mass into mice in addition to sham-operated mice (SO). We recorded body mass, food intake, energy expenditure and body composition over 14 weeks. Both male and female mice showed an initial stress-induced loss of body mass, which was more pronounced in males. Subsequently, male HI mice displayed a permanently decreased biological body mass (MBB, body mass exclusive of the implant mass), equivalent to approximately half of the mass of the implant, and obtained by a decrease in fat mass compared to SO males. In contrast, female HI mice rapidly recovered and maintained their initial MBB and body composition following a mass load. Initial lean body mass was maintained in all male and female groups, and energy intake was similar in all male and female groups. Body mass changes could not be explained by measurable changes in energy intake or expenditure. We conclude ...Continue Reading

References

Nov 1, 1978·The American Journal of Clinical Nutrition·P Bradley
Dec 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R B Harris
Mar 1, 1982·Physiology & Behavior·K B Hoyenga, K T Hoyenga
Jul 1, 1997·Physiology & Behavior·R N CortrightS E DiCarlo
Mar 5, 1998·The American Journal of Physiology·S KlausG Heldmaier
Oct 7, 1998·Journal of Applied Physiology·M M MoranR E Grindeland
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Nov 10, 1998·The Journal of Nutrition·J ProllC C Metges
Apr 30, 1999·Physiological Reviews·E Jéquier, L Tappy
Aug 3, 2000·Brain Research Bulletin·R J Wubbels, H A de Jong
Aug 23, 2000·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·R N Cortright, T R Koves
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·T P Stein, C E Wade
Feb 13, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Cabanac
May 31, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R J StubbsJ E Blundell
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Hans-Rudolf Berthoud
Feb 28, 2003·Diabetes·Deborah J CleggStephen C Woods
Apr 15, 2003·The Proceedings of the Nutrition Society·John R SpeakmanJulian G Mercer

❮ Previous
Next ❯

Citations

Sep 30, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Carola W MeyerGerhard Heldmaier
Dec 1, 2004·Neuroreport·Vincenzo Coppola, Lino Tessarollo
Mar 9, 2018·The Journal of Experimental Biology·John R Speakman
Aug 6, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Chengming HuChuchun L Chang
Jul 10, 2021·Journal of Neuroendocrinology·Tina BakeSuzanne L Dickson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved