Gender Disparities in Epidemiology, Treatment, and Outcome for Head and Neck Cancer in Germany: A Population-Based Long-Term Analysis from 1996 to 2016 of the Thuringian Cancer Registry

Cancers
Andreas DittbernerOrlando Guntinas-Lichius

Abstract

This study determined with focus on gender disparity whether incidence based on age, tumor characteristics, patterns of care, and survival have changed in a population-based sample of 8288 German patients with head neck cancer (HNC) registered between 1996 and 2016 in Thuringia, a federal state in Germany. The average incidence was 26.13 ± 2.89 for men and 6.23 ± 1.11 per 100,000 population per year for women. The incidence peak for men was reached with 60-64 years (63.61 ± 9.37). Highest incidence in females was reached at ≥85 years (13.93 ± 5.87). Multimodal concepts increased over time (RR = 1.33, CI = 1.26 to 1.40). Median follow-up time was 29.10 months. Overall survival (OS) rate at 5 years was 48.5%. The multivariable analysis showed that male gender (Hazard ratio [HR] = 1.44; CI = 1.32 to 1.58), tumor subsite (worst hypopharyngeal cancer: HR = 1.32; CI = 1.19 to 1.47), and tumor stage (stage IV: HR = 3.40; CI = 3.01 to 3.85) but not the year of diagnosis (HR = 1.00; CI = 0.99 to 1.01) were independent risk factors for worse OS. Gender has an influence on incidence per age group and tumor subsite, and on treatment decision, especially in advanced stage and elderly HNC patients.

References

Dec 26, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MicheliUNKNOWN EUROCARE Working Group
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Jan 28, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I TinhoferJ D Raguse
May 16, 2015·Cancer Epidemiology·Darien J WeatherspoonIsabel Garcia
May 17, 2015·Surgical Oncology Clinics of North America·Eleni M Rettig, Gypsyamber D'Souza
Oct 1, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gemma GattaUNKNOWN EUROCARE Working Group:
May 18, 2016·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·D TataruJ E Gallagher
Oct 12, 2016·Cancer Medicine·Irene GöllnitzOrlando Guntinas-Lichius
Jan 22, 2017·International Journal of Cancer. Journal International Du Cancer·Devasena AnantharamanGypsyamber D'Souza
Jun 16, 2017·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Moustafa MouradMark L Urken
Sep 28, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·G B HalmosB A C van Dijk
Nov 7, 2017·Oral Oncology·Nosayaba Osazuwa-PetersMark A Varvares
Feb 16, 2018·Acta Oncologica·Kathrine Kronberg JakobsenChristian von Buchwald
Aug 22, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tyler A JanzEric J Lentsch
Nov 14, 2019·Cancer·Adam Thompson-HarveyNosayaba Osazuwa-Peters
Jan 2, 2020·The New England Journal of Medicine·Laura Q M Chow

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Citations

Feb 1, 2021·Journal of Cancer Research and Clinical Oncology·Lisa MorkramerOrlando Guntinas-Lichius
May 30, 2021·The Laryngoscope·Jovanna ThielkerOrlando Guntinas-Lichius
Nov 23, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mussab KoukaOrlando Guntinas-Lichius

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Methods Mentioned

BETA
ESR
surgical resection

Software Mentioned

SPSS
SAS

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