Gender distribution in irritable bowel syndrome is proportional to the severity of constipation relative to diarrhea

Gender Medicine
Jeremy HermanMark Pimentel

Abstract

A significant gender disparity has been observed in individuals with irritable bowel syndrome (IBS), with females outnumbering males, especially in constipation-predominant IBS (C-IBS). However, this observation is based on Rome criteria categorization and does not take into account the severity of constipation or diarrhea. In a large prospective data set, gender differences across the severity of constipation and diarrhea were examined in patients with IBS. Consecutive adult patients with Rome I positive IBS who were referred to a tertiary care medical center (Cedars-Sinai Medical Center, Los Angeles, California) in 1999-2003 were given a questionnaire. The questionnaire asked subjects to rate their constipation and diarrhea according to perceived severity using a scale from 0 (none) to 5 (very severe). C-IBS was determined to be present if the severity of constipation was greater than the severity of diarrhea (sevC > sevD). If sevD > sevC, subjects were considered to have diarrhea-predominant IBS (D-IBS). To further categorize their symptoms, subjects were then grouped by the difference between the severity of constipation and diarrhea, creating a range of values from -5 to +5. For each of these 11 constipation/diarrhea sever...Continue Reading

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Citations

Feb 11, 2012·Journal of Neurogastroenterology and Motility·Sanam Javid AnbardanHossein Ajdarkosh
Apr 5, 2012·Gastroenterology Research and Practice·Linda Bjork OlafsdottirBjarni Thjodleifsson
Jun 5, 2016·Gastroenterology Clinics of North America·Lucinda A HarrisMargaret M Heitkemper
Jun 3, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D K PrusatorB Greenwood-Van Meerveld
Jan 3, 2018·Journal of Neurogastroenterology and Motility·Beverley Greenwood-Van Meerveld, Anthony C Johnson
Jan 1, 2012·Clinical Medicine Insights. Gastroenterology·Mahmoud Soubra, Ron Schey
Jul 25, 2017·BMC Infectious Diseases·Kinley Wangdi, Archie Ca Clements
Oct 14, 2018·The American Journal of Gastroenterology·James K RuffleQasim Aziz
Jun 5, 2013·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Mariette BengtssonBodil Ohlsson
Jun 8, 2021·Frontiers in Endocrinology·Sik Yu So, Tor C Savidge

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