Gender effects of acute malathion or zinc exposure on the antioxidant response of rat hippocampus and cerebral cortex

Basic & Clinical Pharmacology & Toxicology
Angelica Francesca MarisAlcir Luiz Dafre

Abstract

Gender is one of the most important factors in mammalian development and response to exogenous agents. Although there is increasing evidence that health effects of toxic xenobiotics differ in prevalence or are manifested differently in male and female, the molecular mechanisms related to these events remain unclear. In order to investigate the possible influence of gender, male and female Wistar rats from the same litter were exposed to zinc chloride (5 mg/kg, i.p.) or malathion (250 mg/kg, i.p.) 24 hr prior to the analyses of biochemical parameters related to the cholinergic and glutathione-antioxidant systems in cerebral cortex and hippocampus. After treatments, acetylcholinesterase (AChE) activity was reduced in the hippocampus and cerebral cortex of male and female rats treated with malathion, but the effect was more pronounced in the male group. Glutathione reductase (GR) and γ-glutamyl-transpeptidase activities were reduced in the hippocampus of males and females and a gender-specific effect of malathion was seen for glutathione S-transferase (GST), which was decreased only in male hippocampus and cortex, and for male cortical GR. Zinc chloride treatment decreased AChE activity in male and female cerebral cortex, with no ...Continue Reading

References

Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Jan 1, 1981·Methods in Enzymology·A Wendel
Jan 1, 1981·Methods in Enzymology·W H Habig, W B Jakoby
Aug 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Aschner
Jul 22, 1999·Toxicology Letters·B D BanerjeeA K Chakraborty
Apr 28, 2000·Intensive Care Medicine·V PettiläP Tukiainen
May 2, 2001·Nature Reviews. Neuroscience·M L Wong, J Licinio
Aug 8, 2001·International Journal of Toxicology·M S Christian
Aug 8, 2001·International Journal of Toxicology·R Czerniak
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 17, 2004·Occupational Medicine·R Kamanyire, L Karalliedde
Sep 28, 2005·Archives of Toxicology·M StefanidouC Spiliopoulou
Feb 9, 2006·Neurotoxicity Research·Jucéla J FortunatoJoão Quevedo
Mar 28, 2006·Chemico-biological Interactions·Jeferson L FrancoAlcir L Dafre
Jun 14, 2006·Neurochemical Research·Jucélia J FortunatoJoão Quevedo
Nov 14, 2006·Environmental Research·Marie VahterDeborah Cory-Slechta
Dec 5, 2006·Neurotoxicology·Diane S RohlmanLinda McCauley
Dec 13, 2006·Environmental Research·Audrey M CummingsRobert J Kavlock
Mar 1, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Patrícia S BrocardoAna Lúcia S Rodrigues
Mar 27, 2007·Free Radical Biology & Medicine·Glenda M BishopStephen R Robinson
May 19, 2007·Reviews on Environmental Health·Kushik Jaga, Chandrabhan Dharmani
Sep 27, 2007·Journal of Leukocyte Biology·Jason L Sperry, Joseph P Minei
Oct 5, 2007·Biological Trace Element Research·Sławomir Tubek
Mar 18, 2008·Basic & Clinical Pharmacology & Toxicology·Rafael TrevisanAlcir L Dafre
Apr 9, 2008·Marine Environmental Research·Jeferson L FrancoAlcir L Dafre
Jun 5, 2008·Expert Opinion on Drug Metabolism & Toxicology·Marissa J ScandlynRhonda J Rosengren
Jul 8, 2008·Neurobiology of Aging·Amy S NakashimaRichard H Dyck
Jul 12, 2008·Journal of Agricultural and Food Chemistry·Gislaine Z RéusJoão Quevedo
Dec 6, 2008·British Journal of Biomedical Science·M A El-Nabi Kamel, M Shehata
May 12, 2009·Toxicology Letters·Jeferson L FrancoAlcir L Dafre
Jul 29, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Delphine WaniusiowCécile Parietti-Winkler
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Christopher J GordonUrmila P Kodavanti
Nov 1, 2005·Environmental Toxicology and Pharmacology·Fabrício L AssiniReinaldo N Takahashi

❮ Previous
Next ❯

Citations

Jan 21, 2016·Basic & Clinical Pharmacology & Toxicology·Ahmad A El-EbiaryAhmed A Hashem
Nov 7, 2019·Basic & Clinical Pharmacology & Toxicology·Anne Suély Pinto SavallSimone Pinton
May 21, 2018·Archives of Environmental Contamination and Toxicology·Kelly M Correia, Delbert L Smee
Jan 4, 2019·Journal of Molecular Neuroscience : MN·Joanna A RuszkiewiczMichael Aschner
Oct 25, 2017·Current Environmental Health Reports·Nicole Comfort, Diane B Re
Jun 21, 2018·Frontiers in Genetics·Carolina Torres-Rojas, Byron C Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.