Gender in atrial fibrillation: Ten years later

Gender Medicine
Hector I MichelenaMichael D Ezekowitz

Abstract

Atrial fibrillation (AF) is the most common arrhythmia encountered in both male and female patients. This evidence-based update attempts to address the advances in the science of AF management in light of key gender issues. In October 2009, 2 investigators (H.I.M. and B.D.P.) independently searched MEDLINE (PubMed [1950-2009] and Ovid [2000-2009]) for all publication types in the English language, using database-specific controlled vocabulary describing the concepts of AF and gender (atrial fibrillation, gender, women, and men for PubMed; atrial fibrillation and gender for Ovid). The reference sections from the identified publications were also used. The methodologic quality of publications, their content relevance, and the authors' expert opinions guided publication inclusion in this evidence-based narrative review. Articles relevant to gender differences in pathophysiology, outcomes, and treatment of AF are summarized and discussed. Based on current available data, mortality is greater for women with AF than for men with AF. Women with AF have a higher risk of stroke compared with their male counterparts. Women derive the greatest benefit from anticoagulation in AF. There are no significant sex differences in major bleeding r...Continue Reading

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