Gender influences the magnitude of the inflammatory response within embolic cerebral infarcts in young rats

Stroke; a Journal of Cerebral Circulation
K LiL R Schultz

Abstract

The inflammatory response within cerebral infarcts may have an influence on tissue damage. Since old animals with an impaired immune response have decreased inflammation after experimental cerebral infarction, we postulated that female animals with an increased immune response will have an increased inflammatory response after cerebral infarction. Embolic cerebral infarcts were produced by photochemical irradiation of the right carotid artery in 12 female Fischer rats. The inflammatory response within 4-day-old infarcts was quantitated by histology with the use of computer-assisted image analysis and compared with that in 12 male rats from a previous series. Severe infarcts had the most pronounced inflammatory response. Female rats had an increased inflammatory response in infarcts of all severity, which was statistically significant in severe cerebral infarcts even after adjustment for infarct size. Severe infarcts in males were significantly larger than those in females. Gender influences the outcome of embolic cerebral infarcts after photochemical damage to the carotid artery, both in terms of the magnitude of the inflammatory response and infarct size. There are numerous gender-related differences in neurochemicals, cytokin...Continue Reading

References

Jul 13, 1978·The New England Journal of Medicine·UNKNOWN Canadian Cooperative Study Group
Sep 16, 1992·JAMA : the Journal of the American Medical Association·J H GurwitzJ Avorn
Jan 1, 1990·Annals of Neurology·D Giulian, C Robertson
Feb 1, 1990·Journal of Steroid Biochemistry·A H Schuurs, H A Verheul
Jan 1, 1989·International Archives of Allergy and Applied Immunology·I MalavéR C Williams
May 2, 1970·Nature·S BenköG Petri
May 7, 1971·Brain Research·L F EngB Gerstl
Dec 30, 1994·Annals of the New York Academy of Sciences·J A SechzerC L Wilkens
Jul 1, 1994·Brain Pathology·L F Eng, R S Ghirnikar
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·E UlvestadH Nyland
Jan 1, 1993·International Journal of Immunopharmacology·Y Chen, A G Johnson

❮ Previous
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Citations

Mar 19, 2013·Pflügers Archiv : European journal of physiology·Melinda E Wilson
Oct 21, 2000·Progress in Neurobiology·L M Garcia-SeguraL L DonCarlos
Mar 24, 2005·Journal of Neurotrauma·Jean F SoustielEugene Vlodavsky
Apr 28, 2004·ILAR Journal·Stephanie J MurphyJoanne M Smith
Jun 25, 2008·Journal of Translational Medicine·Jesse T Lang, Louise D McCullough
Feb 13, 2010·Experimental & Translational Stroke Medicine·Stefan Braeuninger, Christoph Kleinschnitz
Dec 14, 2011·Neurobiology of Aging·Danielle K LewisFarida Sohrabji
Aug 12, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anjana MunshiA Jyothy
May 14, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masayoshi UchidaPatricia D Hurn
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M SawadaP D Hurn
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P D Hurn, I M Macrae
Nov 19, 2014·CNS Neuroscience & Therapeutics·TaeHee Kim, Raghu Vemuganti
Jan 22, 2005·European Journal of Pharmacology·Yangzheng FengMichael H LeBlanc
Apr 11, 2000·Neurologic Clinics·A M Demchuk, A M Buchan
May 1, 1997·Clinical Rehabilitation·T B WyllerE Bautz-Holter
Sep 25, 2017·MOJ Toxicology·Shashank ShekharFan Fan
Mar 4, 1998·Current Opinion in Neurology·K J Becker
May 18, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N A Pizov, N V Pizova

❮ Previous
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