PMID: 11340102May 8, 2001Paper

Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects

The Journal of Nutrition
X H ZhangD J Maslin

Abstract

Early trials of garlic preparations on blood lipids mainly supported a lipid-lowering effect, whereas later well-designed garlic tablet trials were mainly entirely null. However, enteric simulation tests suggest that this discordance may result from ineffective delivery of bioactive agents from the brands of garlic powder (GP) and cyclodextrin-bound garlic oil (GO) tablets tested in some recent negative trials. In contrast, enteric simulation tests show that the preformed bioactive agents present in "traditional" gelatin capsules of GO are efficiently released, although such capsules have rarely been investigated in lipid-lowering trials. It was hypothesized that gelatin capsules of GO given to normal subjects would improve specified coronary heart disease risk factors. Effects of a GP preparation were also investigated. Subjects (n = 51; men and women, mean age 27 y) were randomly assigned to receive either 8.2 mg/d of GO (allyl sulfides) or placebo for 11 wk. Another 27 subjects received garlic powder (GP) of similar biopotential (7.8 mg allicin/d). Outcome measures were 95% confidence intervals (CI) between GO and placebo groups for differences between baseline and subsequent sample times. Men and women combined showed no si...Continue Reading

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Citations

Jan 23, 2003·Nutrition Journal·Sanjay K Banerjee, Subir K Maulik
Jan 12, 2012·Journal of the Science of Food and Agriculture·Tao ZengKe-Qin Xie
Mar 26, 2014·Food & Function·Phoebe Zapanta TrioDe-Xing Hou
Mar 13, 2018·Journal of the American College of Nutrition·Sedigheh AsgaryMahtab Keshvari
Nov 11, 2011·Biotechnology Letters·J A KoH J Park
Nov 26, 2011·Expert Review of Clinical Pharmacology·Edward G Lynn, Richard C Austin
Mar 3, 2009·Journal of Clinical Pharmacy and Therapeutics·Y S K Khoo, Z Aziz
Dec 12, 2012·Critical Reviews in Food Science and Nutrition·Tao ZengKe-Qin Xie
Jan 15, 2016·The Journal of Nutrition·Jessica M BradleyDavid J Lefer
Feb 18, 2006·The Journal of Nutrition·Khalid Rahman, Gordon M Lowe
Nov 22, 2007·Journal of Applied Microbiology·E A O'GaraD J Hill
Apr 18, 2013·Nutrition Reviews·Karin RiedPeter Fakler
Jun 27, 2009·Nutrition Research Reviews·Kurt M ReinhartCraig I Coleman
Jan 28, 2012·Allergologia et immunopathologia·Bahaa K A Abdel-Salam, Abd-Alla A A Sayed
Jan 25, 2003·Journal of Natural Products·Caroline Lang'at-ThoruwaPatricia A Murphy
Mar 12, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S K BanerjeeS K Maulik

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