Gender-related difference in left ventricular diastolic elastance during exercise in patients with diabetes mellitus

Circulation Journal : Official Journal of the Japanese Circulation Society
Jong-Won HaNamsik Chung

Abstract

Because the ratio of mitral inflow and annular velocity to stroke volume has been reported as an index of diastolic elastance (Ed), the hypothesis tested in the present study was that Ed during exercise would be more abnormal in female than in male patients with type 2 diabetes. Ed was measured at rest and during graded supine bicycle exercise (25W, 3-min increments) in 53 patients (27 males, mean age 53+/-14 years) with type 2 diabetes and 53 age- and gender-matched controls. The patients with diabetes were divided into 2 groups by gender. Ed was not significantly different at rest between men and women, but was significantly higher during exercise in women than in men (25 W, 0.15+/-0.04 vs 0.20+/-0.07, p=0.009; 50 W, 0.16+/-0.05 vs 0.21+/-0.08, p=0.0175). Left ventricular (LV) diastolic elastance is abnormal during exercise, but not at rest, in patients with diabetes without overt heart disease. Female gender was associated with increased LV stiffness during exercise among patients with type 2 diabetes.

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Citations

Jul 16, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Ae Young HerNamsik Chung
Feb 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yan WangHenan Zhao
Mar 17, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eui-Young ChoiJong-Won Ha
Sep 7, 2011·Vascular Medicine·Amy G HuebschmannJudy G Regensteiner
Oct 14, 2011·Current Opinion in Cardiology·Dawn C Scantlebury, Barry A Borlaug
Mar 11, 2016·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zhao-Jun LiXiang-Hong Luo
Jul 16, 2020·Journal of the Endocrine Society·Layla A AbushamatJane E B Reusch
Nov 6, 2020·Korean Circulation Journal·Chi Young Shim
Mar 19, 2021·Cardiovascular Research·Saraschandra VallabhajosyulaVirginia M Miller
Aug 20, 2021·Therapeutic Advances in Endocrinology and Metabolism·Jian L YeoGaurav S Gulsin

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