Gender-Related Differences in Gastroparesis

The American Journal of the Medical Sciences
Zorisadday GonzalezRichard W McCallum

Abstract

Gastroparesis is a disorder where the stomach empties contents too slowly into the small intestine with associated symptoms of nausea, vomiting, postprandial fullness, bloating, early satiety and/or abdominal pain. It is a well-established fact that the female gender is more susceptible to developing gastroparesis compared to males, although the significance and rationale behind this gender inequality remains an unresolved mystery. Several hypotheses have been proposed including an intrinsically slower stomach in females, elevated levels of sex steroid hormones, loss of neuronal nitric oxide (nNOS) expression, and possibly due to altered serotonergic signaling. Recently, our group investigated gender-associated differences in the number of interstitial cells of Cajal in the antral and pyloric smooth muscle of diabetic patients with severe refractory gastroparesis and found there was no significant difference between the 2 genders. Targeting these gender-specific mechanisms may lead towards future therapeutic options that might alleviate and/or prevent gastroparesis. Furthermore, a better-understanding of the sex-related differences in gastroparesis can allow medical practitioners to better tailor treatment options for their pat...Continue Reading

References

Aug 2, 1975·Lancet·J S Davison
Apr 1, 1976·The American Journal of Digestive Diseases·J H MeyerR Cavalieri
Oct 1, 1992·Digestive Diseases and Sciences·J L Madsen
Jan 1, 1991·Digestive Diseases and Sciences·G TriadafilopoulosD L Goldenberg
Jan 1, 1989·Gastroenterology·W R HutsonA Wald
Jan 1, 1988·British Journal of Anaesthesia·K H SimpsonM Miller
Apr 1, 1986·Gastroenterology·S HoltJ H Wallace
Jan 1, 1987·Digestion·R C GillY J Kingma
May 1, 1986·Digestive Diseases and Sciences·M Davis, J P Ryan
Jun 1, 1985·Gastroenterology·R C GillY J Kingma
Jul 1, 1985·British Journal of Obstetrics and Gynaecology·M HorowitzD J Shearman
Jun 4, 1966·Lancet·G H GriffithR Shields
Jan 1, 1970·The Journal of Obstetrics and Gynaecology of the British Commonwealth·J S DavisonD M Hay
Jun 1, 1984·Digestive Diseases and Sciences·J G MooreN Alazraki
Aug 1, 1984·Clinical Science·M HorowitzD J Shearman
Nov 1, 1982·Digestive Diseases and Sciences·A WaldR Lester
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T CoşkunB C Yeğen
Jan 1, 1993·Anaesthesia·E M WhiteheadG O'Sullivan
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NishizawaM Diksic
Sep 2, 1998·European Journal of Nuclear Medicine·R BenninkL Mortelmans
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·B D MaesP J Rutgeerts
Sep 28, 1999·Scandinavian Journal of Gastroenterology·A M Caballero-PlasenciaJ M Esteban-Carretero
Jul 14, 2000·The American Journal of Gastroenterology·G TougasR W McCallum
Feb 24, 2001·Diabetologia·E A Gale, K M Gillespie
Jul 27, 2001·The American Journal of Gastroenterology·B MearadjiA A Masclee
Aug 25, 2001·Journal of Gastroenterology·M ChiloiroG Riezzo
Apr 2, 2002·World Journal of Gastroenterology : WJG·Chuan-Yong LiuPaulus S Wang
Feb 20, 2003·The American Journal of Gastroenterology·Margaret M HeitkemperEleanor F Bond
Nov 18, 2003·Alimentary Pharmacology & Therapeutics·N S ColemanR C Spiller
Apr 8, 2004·World Journal of Gastroenterology : WJG·Qing-Lin LongYuan-Hui Luo
Jun 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CamilleriDennis A Revicki
Dec 22, 2005·BMC Women's Health·Leszek A RybaczykDonald L Holzschu

❮ Previous
Next ❯

Citations

Jul 18, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Angela E DeanSayeepriyadarshini Anakk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Disease Primers
Medsurg Nursing : Official Journal of the Academy of Medical-Surgical Nurses
Karen Hein Gregg
Revista de gastroenterología de México
M González-Martínez
Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
A Accarino
Gastroenterology Clinics of North America
Gary W Falk
© 2022 Meta ULC. All rights reserved