Gender-related differences in outcome for melanoma patients.

Annals of Surgery
Charles R ScogginsSunbelt Melanoma Trial

Abstract

To better understand the factors associated with the well-established gender difference in survival for patients with melanoma. Gender is an important factor in patients with cutaneous melanoma. Male patients have a worse outcome when compared with females. The reasons for this difference are poorly understood. This prospective multi-institutional study included patients aged 18 to 70 years with melanomas > or =1.0 mm Breslow thickness. Wide excision and sentinel lymph node (SLN) biopsy was performed in all patients. Clinicopathologic factors, including gender, were assessed and correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS). A total of 3324 patients were included in the covariate analyses; 1829 patients had follow-up data available and were included in the survival analyses. Median follow-up was 30 months. On univariate analysis, men (n = 1906) were more likely than women to be older than 60 years (P < 0.0001), have thicker melanomas (P < 0.0001), have primary tumor regression (P = 0.0054), ulceration (P < 0.0001), and axial primary tumor location (P < 0.0001). On multivariate analysis, age (P = 0.0002), thickness (P < 0.0001), ulceration (P = 0.015), and location (...Continue Reading

References

Nov 1, 1992·Seminars in Surgical Oncology·C M Balch
Aug 20, 1992·The New England Journal of Medicine·G CocconiP Costa
Dec 20, 1989·Journal of the National Cancer Institute·W H ClarkA C Halpern
Nov 1, 1994·Annals of Surgical Oncology·P F AustinD S Reintgen
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E GershenwaldM I Ross
Sep 2, 1999·British Journal of Cancer·B RichardsonS Mac Neil
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P B ChapmanJ M Kirkwood
Apr 21, 2001·Annals of Surgical Oncology·K M McMastersM J Edwards
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Dec 19, 2002·American Journal of Surgery·Celia ChaoUNKNOWN Sunbelt Melanoma Trial Group
May 8, 2003·Annals of Surgical Oncology·Grant W CarlsonCynthia Cohen
Sep 26, 2003·Cancer·Marko B LensAmna F Husain
Mar 3, 2004·Annals of Surgical Oncology·Celia ChaoKelly M McMasters
Jun 29, 2004·Journal of Surgical Oncology·Kelly M McMastersUNKNOWN Sunbelt Melanoma Trial
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan H LeeDonald L Morton
Jun 28, 2005·Journal of the American College of Surgeons·Michael S SabelTimothy M Johnson

❮ Previous
Next ❯

Citations

Apr 22, 2009·Archives of Dermatology·Porcia T BradfordMargaret A Tucker
Dec 4, 2012·Clinical & Experimental Metastasis·Judit DobosAndrea Ladányi
Jan 25, 2008·Gender Medicine·Harry Dao, Rebecca A Kazin
May 30, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Angelika Kirsch
Jul 24, 2010·European Journal of Public Health·Willi Oberaigner, Uwe Siebert
Mar 26, 2009·Journal of the National Cancer Institute·Bonnie E Gould RothbergDavid L Rimm
Mar 12, 2010·Pigment Cell & Melanoma Research·Arjen JoosseJan Willem W Coebergh
May 2, 2012·Journal of Skin Cancer·Marcelo MorenoVanessa Gheno
Jul 13, 2012·Environmental Health : a Global Access Science Source·Katarina VolkovovaMaria Dusinska
Jan 9, 2009·Annals of Surgical Oncology·Chris C LeeDonald L Morton
Dec 8, 2009·Annals of Surgical Oncology·Charles R ScogginsKelly M McMasters
Oct 16, 2012·Annals of Surgical Oncology·Michael E EggerCharles R Scoggins
Nov 1, 2011·PloS One·Hazem El-OstaRazelle Kurzrock
Sep 27, 2013·Anais Brasileiros De Dermatologia·Camila Maria Arruda VilanovaSabas Carlos Vieira
Dec 18, 2013·American Journal of Surgery·Alison L BurtonGlenda G Callender
Aug 29, 2012·Surgery·Michael E EggerKelly M McMasters
Oct 18, 2011·Surgery·Christina Tragos, Tina J Hieken
Mar 30, 2010·Medical Hypotheses·Marina Kvaskoff, Philip Weinstein
Mar 2, 2012·The Journal of Investigative Dermatology·Maryam M AsgariEmily White
Dec 15, 2010·The Journal of Investigative Dermatology·Arjen JoosseUNKNOWN Munich Melanoma Group
Oct 28, 2008·Brain, Behavior, and Immunity·Ranit NaorShamgar Ben-Eliyahu
Sep 11, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D RoulinF J Lejeune
Mar 6, 2007·Surgical Oncology Clinics of North America·John F Thompson, Helen M Shaw
Jan 8, 2008·Experimental Dermatology·Mary Alice NadingDarrel L Ellis
Oct 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·K AzarjanaD Pjanova
Sep 28, 2012·The British Journal of Dermatology·V de GiorgiD Massi
Apr 28, 2011·Cancer·Jules GadiotChristian Blank
Jul 23, 2011·Journal of Clinical Nursing·Senada HajdarevicAsa Hörnsten
Dec 15, 2010·American Journal of Surgery·Nathaniel P ReuterAnees B Chagpar
Jul 31, 2014·American Journal of Preventive Medicine·Estee L WilliamsDaniel M Siegel
Jul 17, 2015·Pathology Oncology Research : POR·Melinda FábiánSarolta Kárpáti
Apr 16, 2016·Nature Reviews. Cancer·Andrea ClocchiattiG Paolo Dotto
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 2, 2016·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·I KoskivuoE Suominen
May 30, 2007·British Journal of Cancer·R M MacKieUNKNOWN Scottish Melanoma Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.