Gender-related mortality trends among diabetic patients with ST-segment elevation myocardial infarction: insights from a nationwide registry 1997-2010

European Heart Journal. Acute Cardiovascular Care
Marco RoffiAMIS Plus Investigator

Abstract

Data on temporal trends in outcomes, gender differences, and adherence to evidence-based therapy (EBT) of diabetic patients with ST-segment elevation myocardial infarction (STEMI) are sparse. We performed a retrospective analysis of prospectively acquired data on 3565 diabetic (2412 males and 1153 females) STEMI patients enrolled in the Swiss AMIS Plus registry between 1997 and 2010 and compared in-hospital outcomes and adherence to EBT with the nondiabetic population (n=15,531). In-hospital mortality dramatically decreased in diabetic patients, from 19.9% in 1997 to 9.0% in 2010 (p trend<0.001) with an age-adjusted decrease of 6% per year of admission. Similar trends were observed for age-adjusted reinfarction (OR 0.86, p<0.001), cardiogenic shock (OR 0.88, p<0.001), as well as death, reinfarction, or stroke (OR 0.92, p<0.001). However, the mortality benefit over time was observed in diabetic males (p trend=0.006) but not females (p trend=0.082). In addition, mortality remained twice as high in diabetic patients compared with nondiabetic ones (12.1 vs. 6.1%, p<0.001) and diabetes was identified as independent predictor of mortality (OR 1.23, p=0.022). Within the diabetic cohort, females had higher mortality than males (16.1 vs...Continue Reading

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Citations

Jun 30, 2015·Journal of Women's Health·Eva de-Miguel-BalsaUNKNOWN ARIAM-SEMICYUC group
Jul 30, 2015·Diabetes Technology & Therapeutics·Wen YeWilliam H Herman
Apr 16, 2015·European Heart Journal·Thomas F Lüscher
Mar 1, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Christina LuongJacqueline Saw
Apr 9, 2016·JACC. Cardiovascular Imaging·Marysia S TweetSharonne N Hayes
Jun 5, 2018·European Heart Journal. Acute Cardiovascular Care·Baris GencerMarco Roffi
Sep 28, 2018·European Heart Journal. Acute Cardiovascular Care·Xavier RosselloUNKNOWN High-Risk Myocardial Infarction Database Initiative
Aug 28, 2019·European Heart Journal. Acute Cardiovascular Care·Romana HerscoviciMichael Goldfarb
Oct 14, 2021·BMC Endocrine Disorders·Fadia Abdallah Mayyas, Khalid Shaker Ibrahim

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

AMIS
SPSS

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