Gender related similarities and differences in the body distribution of grape seed flavanols in rats

Molecular Nutrition & Food Research
Maria MargalefA Arola-Arnal

Abstract

Dietary flavanols produce beneficial health effects, and once absorbed, they are recognized as xenobiotics and undergo phase-II enzymatic detoxification. Flavanols health-promoting properties are mainly attributed to their metabolic products. This work aimed to elucidate whether rats of the opposite sex exhibited differences in the metabolism and distribution of ingested flavanols. To accomplish this aim, acute doses of grape seed polyphenols were administered to male and female rats. After 1, 2 and 4 h, plasma, liver, mesenteric white adipose tissue (MWAT), brain and hypothalamus flavanol metabolites were quantified by HPLC-MS/MS. Results indicated important sex-related quantitative differences in plasma and in brain. Moreover, remarkable sex-related differences in the distributions and types of flavanol metabolites were also observed between liver and brain. Therefore, this study demonstrated that sex differentially influences the metabolism and distribution of flavanols throughout the bodies of rats, which may affect the physiological bioactivities of flavanols between males and females. This article is protected by copyright. All rights reserved.

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Citations

Nov 4, 2016·Molecular Nutrition & Food Research·Maria MargalefBegoña Muguerza
Jul 28, 2016·Journal of Animal Physiology and Animal Nutrition·D K GessnerK Eder
Jun 28, 2017·Molecular Nutrition & Food Research·Janet A NovotnyMario G Ferruzzi
Jan 8, 2019·Critical Reviews in Food Science and Nutrition·Danyue ZhaoQingli Wu
Apr 14, 2019·Molecular Nutrition & Food Research·Iris GinésAnna Ardévol
Jul 20, 2019·Nutrients·Ilaria CampesiFlavia Franconi
Jan 8, 2020·Nutrients·Carlos González-QuilenXimena Terra
Aug 19, 2020·Food & Function·Anna Arola-ArnalAlberto Dávalos
Sep 8, 2018·International Journal of Molecular Sciences·Aïda Pascual-SerranoAnna Arola-Arnal
Jan 6, 2021·Food & Function·Miguel Z Martín-GonzálezGerard Aragonès
Mar 31, 2021·Brain Plasticity·Rafael CarechoCláudia Nunes Dos Santos
Dec 17, 2021·Journal of Food Biochemistry·Xiaoping LiTing Luo

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