PMID: 11907168Mar 22, 2002Paper

Gender-specific and developmental influences on the expression of rat organic anion transporters

The Journal of Pharmacology and Experimental Therapeutics
Susan C N BuistC D Klaassen

Abstract

Rat organic anion transporter 1 (Oat1), Oat2, and Oat3, members of the organic anion transporter family, transport some organic anions across cellular membranes. Previously, highest Oat1 and Oat3 mRNA expression was reported in kidney and Oat2 in liver. However, gender and developmental differences in Oat expression remain unknown. This study describes gender- and age-specific patterns of rat organic anion transporter expression in various tissues. Oat mRNA expression was evaluated in adult male and female Sprague-Dawley rat tissues, and developmental expression was also determined in kidneys of Sprague-Dawley rats ranging in age from days 0 through 45. Expression was quantified using branched-DNA signal amplification. Oat1 mRNA expression was primarily observed in kidney. Surprisingly, Oat2 mRNA expression was also highest in kidney rather than in liver. Moreover, considerably higher Oat2 levels were seen in female kidney as compared with male. Finally, Oat3 mRNA expression was highest in kidney of both genders, whereas a male-predominant pattern was observed in liver. At birth, all kidney Oat mRNA levels were low. Renal Oat1 expression gradually increased throughout development, approaching adult levels at 30 days of age, whe...Continue Reading

References

Aug 1, 1975·The Journal of Infectious Diseases·B M Tune
Jan 1, 1990·European Journal of Clinical Pharmacology·J I MacdonaldR K Verbeeck
Oct 1, 1993·Physiological Reviews·J B Pritchard, D S Miller
Jul 25, 1997·The Journal of Biological Chemistry·T SekineH Endou
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Dec 31, 1997·The Journal of Biological Chemistry·D H SweetJ B Pritchard
Mar 2, 1999·Biochemical and Biophysical Research Communications·J E RaceE J Holtzman
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·A TojoH Endou
Sep 24, 1999·Drugs·V Fanos, A Dall'Agnola
Oct 2, 2001·AIDS·F RouetUNKNOWN Abidjan DITRAME Study Group (ANRS 049 clinical trial)

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Citations

May 17, 2005·Pflügers Archiv : European journal of physiology·Vladiana CrljenIvan Sabolić
Jul 20, 2007·Pflügers Archiv : European journal of physiology·Ivan SabolićGerhard Burckhardt
Dec 7, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nancy ChenGideon Koren
Aug 26, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jose L ReyesEstela Melendez
Apr 17, 2008·Journal of Human Genetics·Ken OgasawaraKen-Ichi Inui
Jan 25, 2007·Pharmaceutical Research·Ahsan N Rizwan, Gerhard Burckhardt
Jul 2, 2009·Environmental Health and Preventive Medicine·Kouji H Harada, Akio Koizumi
Mar 24, 2004·Toxicology·John L ButenhoffRaymond G York
Nov 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yi M WeaverBruno Hagenbuch
Apr 17, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julia Yue CuiCurtis D Klaassen
Sep 28, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary Sue MartyLarry Hammond
Mar 20, 2008·Current Opinion in Rheumatology·Atsuo Taniguchi, Naoyuki Kamatani
Dec 17, 2003·Kidney International·Tsuneo DeguchiYuichi Sugiyama
Apr 16, 2011·Molecular Pharmacology·Derina E SweeneySanjay K Nigam
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Aug 12, 2009·Antimicrobial Agents and Chemotherapy·Michele Di MascioDale Kiesewetter
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hua XuFayez K Ghishan
Feb 14, 2008·Physiological Genomics·Satish A EralySanjay K Nigam
Jan 17, 2008·Environmental Health Perspectives·David A AremuNazzareno Ballatori
Mar 28, 2009·International Journal of Molecular Sciences·Peter G Mantle, Judit M Nagy
Dec 1, 2012·World Journal of Gastroenterology : WJG·Anabel BrandoniAdriana Mónica Torres
Nov 29, 2014·Veterinary Medicine International·Ana Paula PradosMarcela Rebuelto
May 13, 2014·Reproductive Toxicology·David M KleinNathan J Cherrington
Nov 4, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·David T SzaboLinda S Birnbaum
Feb 8, 2013·American Journal of Physiology. Renal Physiology·Davorka BreljakIvan Sabolic
Nov 21, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Simona De GregoriMauro Stronati
Sep 7, 2006·Drug Development and Industrial Pharmacy·D R TaftI A Savant
Sep 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Nov 12, 2010·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanFederica Chiara
Mar 4, 2005·Critical Reviews in Toxicology·Evelyn O'Brien, Daniel R Dietrich
Dec 3, 2004·Drug and Chemical Toxicology·Xing HanGary W Jepson
Apr 23, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eline M RodenburgLoes E Visser
Oct 6, 2012·Pediatric Clinics of North America·Ryan S FunkSusan M Abdel-Rahman
Jul 31, 2012·Pharmacology & Therapeutics·Gerhard Burckhardt
Sep 12, 2009·Pharmacology & Therapeutics·Peng Duan, Guofeng You
Oct 18, 2008·Reproductive Toxicology·Loeckie de ZwartGeert S Mannens
Jun 25, 2008·Gender Medicine·Raymond HreicheJacques Turgeon
Feb 14, 2007·Biochemical Pharmacology·Kumiko NishiharaKen-Ichi Inui

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