Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 With Bone Health and Fractures in Older Persons

The Journal of Clinical Endocrinology and Metabolism
N C van VarsseveldPaul Lips

Abstract

IGF-1 plays a role in bone metabolism. Although IGF-1 and bone mass both decrease with advancing age, their relationship in older individuals remains to be elucidated. The objective was to investigate associations of serum IGF-1 cross-sectionally with quantitative ultrasound and bone mineral density (BMD), and longitudinally with 3-year change in BMD and 10-year fracture risk in older individuals. The study included 627 men and 656 women aged ≥ 65 years from the Longitudinal Aging Study Amsterdam, an ongoing, population-based cohort study. Main outcome measures included baseline serum IGF-1 concentration; baseline quantitative ultrasound of the heel, including broadband ultrasound attenuation and speed of sound; BMD measured at several body sites at baseline and after 3 years; and prospective fracture incidence over 10 years. Associations were adjusted for relevant confounders. Women, but not men, in the lowest quintile of IGF-1 concentration had lower broadband ultrasound attenuation (B = -4.53; P = .03) and a greater 3-year decrease in total hip BMD (B = -0.02; P = .05), than women in the highest quintile of IGF-1. Moreover, compared to women in the highest quintile of IGF-1, women in the combined lowest four quintiles of IGF...Continue Reading

Citations

Jan 4, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Peter HerbertFergal M Grace
Jan 11, 2017·Current Opinion in Rheumatology·Jane A Cauley
Mar 28, 2018·Journal of Molecular Endocrinology·Richard C LindseySubburaman Mohan
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Aug 10, 2019·Hormone Molecular Biology and Clinical Investigation·Shereen M AleidiYasser Bustanji
Jan 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Shuai YuanSusanna C Larsson
Jul 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Keegan BurrowAlaa El-Din Bekhit
Jan 9, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F LvL Ji
May 27, 2020·Gerontology·Katharina Kerschan-SchindlPeter Pietschmann

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