Gender-specific diagnostic performance of a new high-sensitivity cardiac troponin I assay for detection of acute myocardial infarction

European Heart Journal. Acute Cardiovascular Care
Niklas SchoferStefan Blankenberg

Abstract

The determination of cardiac troponin is essential for diagnosing myocardial infarction. A troponin I assay has recently been developed that provides the highest analytical sensitivity to date. The analysis included 1560 patients with chest pain, of whom 1098 were diagnosed with non-coronary chest pain, 189 with unstable angina pectoris and 273 with non-ST-segment elevation myocardial infarction. The troponin I concentration was determined on admission (0 hours) and 3 hours later. The diagnostic algorithm incorporated troponin I elevation above the gender-specific 99th percentile as well as predefined relative or absolute 3-hour changes in the troponin I concentration (delta). The diagnostic criterion of troponin I above the 99th percentile resulted in a negative predictive value of 98.0% and 98.2% in men and women, respectively. For rule-in of non-ST-segment elevation myocardial infarction, the use of absolute deltas yielded higher positive predictive values and sensitivities compared to relative deltas. With detection rates of about 85% and 82% in men and women, respectively, non-ST-segment elevation myocardial infarction was diagnosed with a positive predictive value close to 84% in men and 80% in women. The investigational ...Continue Reading

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Nov 14, 2013·European Heart Journal. Acute Cardiovascular Care·Marc P BonacaDavid A Morrow

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Citations

Apr 10, 2017·Current Cardiology Reports·Anoop S V ShahNicholas L Mills
Nov 5, 2016·Nature Reviews. Cardiology·Gerard PasterkampPeter Libby
Jul 14, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiGian Luca Salvagno
May 26, 2018·Scientific Reports·Jes-Niels BoeckelTill Keller

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

R Core Team
R
R Foundation for Statistical Computing

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