Gender Specific Differences in Disease-Free, Cancer Specific and Overall Survival after Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis

The Journal of Urology
Annemarie UhligJohannes Uhlig

Abstract

We summarize the evidence on gender specific differences in disease-free, cancer specific and overall survival after radical cystectomy for bladder cancer. We performed a systematic literature search of MEDLINE®, Embase® and the Cochrane Library in July 2017. Studies evaluating gender specific differences in disease-free, cancer specific or overall survival after radical cystectomy for bladder cancer were included in study. Analyses included random effect meta-analysis, subgroup analyses, meta-influence and cumulative meta-analyses. Funnel plots and the Egger test were used to assess publication bias. Of the 3,868 studies identified during the literature search 59 published between 1998 and 2017 were included in analysis. Of the studies 30 in a total of 38,321 patients evaluated disease-free survival, 44 in a total of 69,666 evaluated cancer specific survival and 26 in a total of 30,039 evaluated overall survival. Random effect meta-analyses revealed decreased disease-free, cancer specific survival and overall survival in female patients than in their male counterparts. Pooled estimates showed a HR of 1.16 (95% CI 1.06-1.27, p = 0.0018) for disease-free survival, 1.23 (95% CI 1.15-1.31, p <0.001) for cancer specific survival an...Continue Reading

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Citations

Mar 12, 2019·Current Opinion in Urology·Dong-Ho MunMohammad Abufaraj
Aug 1, 2019·Journal of the Royal Society, Interface·Valerio CapraroDaniele Vilone
Jul 28, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Huafu LiChanghua Zhang
May 8, 2020·Current Urology Reports·Wesley YipSumeet K Bhanvadia
Nov 11, 2018·Current Urology Reports·Sumeet K Bhanvadia
Dec 4, 2020·Urologic Oncology·Benjamin V StoneKelvin A Moses
Apr 3, 2021·Frontiers in Endocrinology·Takuro Goto, Hiroshi Miyamoto

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