Gender-specific differences of interaction between cadmium exposure and obesity on prediabetes in the NHANES 2007-2012 population

Endocrine
Fei JiangZengli Zhang

Abstract

Data from National Health and Nutrition Examination Survey (NHANES) for the years 2007-2012 were used to evaluate the interactions of cadmium (Cd) exposure with being overweight/obesity on the risk of prediabetes among adults 20 years older. A total of 3552 subjects were included in the analysis. Urinary cadmium levels (UCd) was used as a biomarker for long-term exposure to Cd. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S). Following covariates adjustments, we found significant associations of UCd with higher prediabetes prevalence, and this association was more apparent in males (Q4 vs Q1: OR = 1.95, 95%CI: 1.34-2.84); while overweight/obesity was associated with prediabetes both in males and in females. Additionally, there was a significant interaction between Cd exposure and being overweight/obesity on prediabetes risk among males (RERI = 1.18, 95% CI: 0.42-1.93; AP = 0.35, 95% CI: 0.12-0.58; S = 2.00, 95% CI: 0.92-4.34). Our results suggest that being overweight/obesity may substantially amplify the adverse effects of long-term cadmium exposure on prediabetes risk, and this interaction is more severe in male adul...Continue Reading

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Citations

Mar 14, 2020·Journal of Applied Toxicology : JAT·Xiaohui LiLianhui Wang
Jan 28, 2021·Journal of Endocrinological Investigation·V M BimonteS Migliaccio
Sep 29, 2020·Toxicology Reports·John C MazzoccoJonathan H Freedman
Apr 24, 2021·Toxicology Reports·Bin ZhouJonathan H Freedman
Aug 8, 2021·International Journal of Environmental Research and Public Health·Anatoly V SkalnyAlexey A Tinkov

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