Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet

Toxicology and Applied Pharmacology
Jing LiHui Wang

Abstract

Prenatal caffeine exposure (PCE) alters the hypothalamic-pituitary-adrenocortical (HPA) axis-associated neuroendocrine metabolic programming and induces an increased susceptibility to metabolic syndrome (MS) in intrauterine growth retardation (IUGR) offspring rats. High-fat diet (HFD) is one of the main environmental factors accounting for the incidence of MS. In this study, we aimed to clarify the gender-specific increase in susceptibility to MS in offspring rats after PCE with post-weaning HFD. Maternal Wistar rats were administered with caffeine (120mg/kg·d) from gestational day 11 until delivery. The offspring rats with normal diet or HFD were euthanized at postnatal week 24, and blood samples were collected. Results showed that PCE not only reduced serum adrenocorticotropic hormone (ACTH) and corticosterone levels, but also enhanced serum glucose, triglyceride and total cholesterol (TCH) concentrations in the offspring rats. Moreover, several interactions among PCE, HFD and gender were observed by a three-way ANOVA analysis. In PCE offspring, HFD could aggravate the degree of increased serum triglyceride level. Meanwhile, serum corticosterone levels of females were decreased more obviously than those of males in PCE offspr...Continue Reading

References

Apr 1, 1991·American Journal of Public Health·L FensterS H Swan
May 24, 1990·The New England Journal of Medicine·C BouchardG Fournier
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·D JaquetC Levy-Marchal
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Peter D Gluckman, Mark A Hanson
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Apr 12, 2007·Obesity·Roland BuettnerL Cornelius Bollheimer
Jun 5, 2007·Trends in Molecular Medicine·Michael J MeaneyJonathan R Seckl
Jan 22, 2009·European Journal of Endocrinology·Thomas ReinehrAndre Michael Toschke
Nov 6, 2009·Behavioural Pharmacology·Jennifer L TempleAmber M Dewey
Nov 11, 2009·Cellular and Molecular Neurobiology·George BoukouvalasEfthimia Kitraki
Feb 23, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Gunilla ThelanderJohan Ahlner
Mar 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C ShinP S MohanKumar
Jun 19, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jennifer David PeckLinda D Cowan
Jul 20, 2010·Archives of Medical Research·Leticia Manuel-ApolinarMarcelino Hernández
Dec 23, 2011·International Journal of Endocrinology·Anna AlisiValerio Nobili
Jan 6, 2012·Arquivos brasileiros de endocrinologia e metabologia·María Isabel Hernández, Verónica Mericq
Jan 17, 2012·Clinical and Experimental Pharmacology & Physiology·Jing HuangHui Wang
Mar 10, 2012·Metabolism: Clinical and Experimental·Emilia Amengual-CladeraAna M Proenza
Jun 23, 2012·Nutrition·Sunil K PanchalLindsay Brown
Jul 3, 2013·Journal of the American College of Cardiology·Hiram Beltrán-SánchezSean McElligott

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Citations

Jul 4, 2018·Journal of Neuroendocrinology·Giselle Adriana AbruzzeseRamón Sotomayor-Zárate
May 3, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dan XuHui Wang
Oct 28, 2019·Children·Vasantha H S Kumar, Steven E Lipshultz
Mar 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hangyuan HeLiaobin Chen

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