Gender-specific neuromuscular adaptations to unloading in isolated rat soleus muscles

Muscle & Nerve
Michael R Deschenes, Colleen M Leathrum

Abstract

The potential of gender to affect unloading-induced neuromuscular adaptations was investigated. Twenty male and 20 female rats were assigned to control (CTL), or unloaded (UL) conditions. After 2 weeks of unloading, soleus muscles were removed, and neuromuscular function was assessed during a train of alternating indirect (neural) and direct (muscle) stimuli. In rested muscle, strength showed significant (P ≤ 0.05) main effects for gender (male > female) and treatment (CTL > UL). By the end of the testing protocol, when muscles showed fatigue, gender-related and treatment-related differences in strength had disappeared. Neuromuscular transmission efficiency and strength suffered a greater decline during the testing protocol in males than females. Unloaded male muscles displayed greater contractile velocity than female muscles both when rested and fatigued. Gender affected unloading-induced neuromuscular adaptations. The greater strength of rested male muscles was due to greater muscle mass and neuromuscular transmission efficiency. Muscle Nerve 54: 300-307, 2016.

References

Apr 1, 1992·Journal of Applied Physiology·B M HatherG A Dudley
Jun 1, 1991·Journal of Applied Physiology·R R RoyV R Edgerton
Sep 1, 1986·Journal of Applied Physiology·T K AldrichH Nagashima
Aug 1, 1986·Journal of Applied Physiology·B Bigland-RitchieJ J Woods
Mar 1, 1972·The Journal of Physiology·T Lomo, J Rosenthal
Mar 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Brown, E M Hasser
Sep 7, 2001·Annals of the New York Academy of Sciences·C L Huntoon
Feb 6, 2002·Medicine and Science in Sports and Exercise·Kimberley SchulzeScott Trappe
Nov 6, 2003·Journal of Applied Physiology·Gregory R AdamsKenneth M Baldwin
Apr 30, 2005·Journal of Applied Physiology·Nobuo YasudaMark A Tarnopolsky
Jul 31, 2007·Muscle & Nerve·Edwin R MulderArnold de Haan
Jan 7, 2009·European Journal of Applied Physiology·Michael R DeschenesMargaret K Eason
May 3, 2011·European Journal of Applied Physiology·K J Hackney, L L Ploutz-Snyder
Jul 19, 2012·Muscle & Nerve·Michael R DeschenesKatherine A Mangis
Jun 27, 2013·The International Journal of Biochemistry & Cell Biology·Sue C Bodine
Dec 10, 2013·Experimental Gerontology·Stephen E AlwaySuzette L Pereira
Mar 20, 2014·European Journal of Applied Physiology·Summer B CookLori L Ploutz-Snyder
Oct 27, 2014·European Journal of Applied Physiology·Enrico RejcMarco Narici
Nov 18, 2014·Journal of Women's Health·Lori Ploutz-SnyderDebra Bemben

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Citations

Dec 17, 2019·Acta Physiologica·Rizwan QaisarAdel B Elmoselhi
Oct 7, 2021·Physiological Reports·Marie MortreuxSeward B Rutkove

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