Gender-specific regulation of pancreatic islet blood flow, insulin levels and glycaemia in spontaneously diabetic Goto-Kakizaki rats

Clinical Science
Zhen HuangAke Sjöholm

Abstract

Patients with diabetes are often treated with a statin for hyperlipidaemia and an ACE (angiotensin-converting enzyme) inhibitor or angiotensin receptor antagonist for hypertension or albuminuria. These drugs may also exert beneficial metabolic effects, causing improved glucose tolerance in patients. Gender-related differences have also been observed in the clinical responsiveness to these drugs, but the mechanism behind this is unclear. In the present study, we have investigated whether these drugs and the fatty acid palmitate influence the pancreatic microcirculation, thereby having an impact on insulin secretion and glycaemia in vivo, in spontaneously diabetic male and female Goto-Kakizaki rats. In male rats, pancreatic IBF (islet blood flow) and total PBF (pancreatic blood flow) were increased significantly by pravastatin, captopril and irbesartan. Serum insulin levels were increased by pravastatin and captopril. Palmitate suppressed pancreatic IBF and increased blood glucose. In female animals, pancreatic IBF was stimulated by captopril, candesartan and irbesartan. Total PBF was increased by captopril, candesartan and irbesartan, and by pravastatin. Palmitate suppressed pancreatic IBF and serum insulin secretion. In conclus...Continue Reading

References

Apr 1, 1977·Physiological Reviews·M J Peach
Apr 1, 1992·Journal of Hypertension·M S GordonM A Shupnik
Jun 1, 1989·The Journal of Clinical Investigation·K E EllisonV J Dzau
Jul 1, 1983·Diabetologia·L Jansson, C Hellerström
Oct 11, 1984·The New England Journal of Medicine·C E WaldenE Strandness
May 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·R KreutzM Paul
Sep 1, 1995·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P CorvolT A Williams
Mar 21, 1998·Journal of the American College of Cardiology·J K WilliamsP Libby
Feb 4, 1999·Hypertension·P E GallagherK B Brosnihan
May 13, 1999·The Journal of Endocrinology·M TahmasebiG P Vinson
Jan 24, 2002·Journal of the American Society of Nephrology : JASN·Mala ChidambaramJudith A Miller
Feb 28, 2002·Cardiovascular Research·Marcus FischerHeribert Schunkert
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Ines ArmandoJuan M Saavedra
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Judy R FreshourKaren L Vikstrom
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Sep 1, 2004·Hypertension·Carmen Hinojosa-LabordeKathryn Sandberg
Jul 2, 2005·Diabetes/metabolism Research and Reviews·Ake Sjöholm, Thomas Nyström
Apr 12, 2006·The International Journal of Biochemistry & Cell Biology·Richard Olsson, Per-Ola Carlsson
May 3, 2006·Biochemical and Biophysical Research Communications·Jiaqing ShaoHirotaka Watada
Jun 8, 2006·Biochemical and Biophysical Research Communications·Zhen HuangAke Sjöholm
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz

❮ Previous
Next ❯

Citations

Dec 29, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xin LiSuosuo Cheng
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Amr A FouadMohamed A Morsy
Jul 3, 2019·Biology of Sex Differences·Melissa C WhiteAmy C Arnold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.