PMID: 9442349Jan 27, 1998Paper

Gender-specific steroid metabolism in neural differentiation

Cellular and Molecular Neurobiology
J B Hutchison

Abstract

1. Both the neuroendocrine system and the brain mechanisms underlying gender-specific behavior are known to be organized by steroid sex hormones, androgen and estrogen, during specific sensitive phases of early fetal and perinatal development. The factors that control these phasic effects of the hormones on brain development are still not understood. Processes of masculinization and defeminization are thought to be involved in the sex differentiation of mammalian reproductive behavior. 2. The P450 aromatase, converting androgen to estrogen, is a key enzyme in the development of neural systems, and the activity of this enzyme is likely to be one of the factors determining brain sex differentiation. 3. We have examined the localization and regulation of brain aromatase using the mouse as a model. Measurement of testosterone conversion to estradiol-17 beta, using a sensitive radiometric 3H2O assay, indicates that estrogens are formed more actively in the male mouse brain than in the female during both the prenatal and the neonatal periods. In primary cell cultures of embryonic mouse hypothalamus there are sex differences in aromatase activity during early and late embryogenesis, with a higher capacity for estrogen formation in the...Continue Reading

Citations

Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·M YoshiokaB A Finette
Nov 30, 2006·Journal of Neuroscience Research·M C OsborneD R Sengelaub
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Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·J B HutchisonR E Hutchison
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Oct 12, 2010·Molecular and Cellular Endocrinology·Betina GonzalezSusana B Rulli

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