PMID: 9661005Jul 14, 1998Paper

Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate

Antimicrobial Agents and Chemotherapy
A Haimeur, M Ouellette

Abstract

Leishmania tarentolae promastigotes were selected step by step for resistance to sodium stibogluconate (Pentostam). Mutants resistant to antimony-containing drugs and cross-resistant to arsenite were therefore obtained. Amplification of one common locus was observed in several independent sodium stibogluconate-resistant mutants, and the locus amplified was novel. The copy number of the amplified locus was related to the level of resistance to pentavalent antimony. The gene responsible for antimony resistance was isolated by transfection and was shown to correspond to an open reading frame coding for 770 amino acids. The putative gene product did not exhibit significant homology with sequences present in data banks, and the putative role of this protein in antimony resistance is discussed.

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Citations

Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Christian BrochuMarc Ouellette
Jan 25, 2007·Journal of Medical Microbiology· AshutoshNeena Goyal
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