Mar 26, 2003

Gene and cancer therapy--pseudorabies virus: a novel research and therapeutic tool?

Current Gene Therapy
Zsolt Boldogkői, Antal Nógrádi

Abstract

The past decade has been marked by significant advances in the application of gene transfer into living cells of animals and humans, with the resulting catapulting of preclinical and basic scientific concepts into therapeutic trials. A variety of virus-mediated gene delivery techniques have proved to be superior to other methodologies. This article concisely reviews the current status of gene and tumor therapy, focusing on virus-based technologies, describes the molecular biology of neurotropic herpesviruses and the application of herpes simplex virus, a relative of pseudorabies virus (PRV) in gene transfer and cancer therapy protocols. Finally, it addresses the issue of whether PRV, a nonhuman pathogen, could serve as a suitable research and therapeutic tool as concerns genetic and tumor therapy.

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Mentioned in this Paper

Shuttle Vectors
Thymic Group Viruses
Gene Transfer Techniques
Pseudorabies
Pathogenic Organism
Simplexvirus
Neonatal Herpes
Herpesvirus 1, Suid
Genetic Therapy, Somatic
Gene Transfer

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