PMID: 6985479May 1, 1981Paper

Gene and mRNA for precursor polypeptide VI from adenovirus type 2

Journal of Virology
G Akusjärvi, H Persson

Abstract

We present a 1,040-base-pair-long sequences of adenoviruses type 2 DNA which encodes the complete gene for precursor polypeptide VI (pVI). pVI consists of 250 amino acids amounting to a molecular weight of 26,990. The proteolytic cleavage maturing pVI to virion polypeptide VI removes 33 amino acids from the amino-terminal end of the polypeptide, thus giving the mature polypeptide VI a molecular weight of 23,400. The UAA stop codon terminating pVI translation is separated by 84 nucleotides from the initiator triplet for the hexon gene. Both polypeptides are encoded by the same translational reading frame, suggesting the evolution of pVI and hexon as separate proteins by the introduction of a termination codon and selection of a new splice acceptor site in an ancestral fused polypeptide chain. The splice site where the common tripartite leader is attached to the pVI mRNA precedes the initiator codon for pVI translation by one nucleotide and forms, together with other late splice acceptor sites, a late adenovirus consensus acceptor site. We also demonstrate that the 3' end of the mRNA's belonging to the L2 3'-cotermination family is located only 31 nucleotides upstream from the splice junction of the pVI mRNA. Furthermore, we show...Continue Reading

References

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Citations

Nov 26, 2014·Viruses·Walter F Mangel, Carmen San Martín
Jun 4, 2014·Virology·Hongxing ZhaoUlf Pettersson
Nov 8, 2001·Journal of Molecular Biology·P S RydmanD H Bamford
Nov 14, 1997·Trends in Biochemical Sciences·W F MangelW J McGrath
Mar 16, 1983·Biochimica Et Biophysica Acta·M L TremblayJ Weber
Oct 1, 1983·Journal of Virology·J M Le MoullecM Perricaudet
Dec 1, 1985·Journal of Virology·G Akusjärvi
Nov 1, 1985·Journal of Virology·J van Oostrum, R M Burnett
Dec 5, 1982·Journal of Molecular Biology·C B Lawrence, K J Jackson

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