PMID: 11336921May 5, 2001Paper

Gene and protein expression of brain-derived neurotrophic factor and TrkB in bone and cartilage

Bone
T YamashiroT Takano-Yamamoto

Abstract

Gene and protein expressions of brain-derived neurotrophic factor (BDNF) and TrkB, the high-affinity receptor of BDNF, were investigated in the femur and mandibular condyle of rats by in situ hybridization and immunohistochemistry. BDNF and TrkB mRNA showed overlapped expression in chondrocytes in proliferating and mature zones of the epiphyseal growth plate cartilage and mandibular condylar cartilage, and in cuboidal-shaped active osteoblasts at the site of endochondral and intramembranous ossification and in trabecular bone. Expression of BDNF protein also showed a similar localization. The present study suggests that BDNF may participate in regulating the development and remodeling of bony tissue in the developing rat.

References

Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K S CheahL Stubbs
Jul 1, 1990·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·J M Dibbets
Jan 1, 1988·Peptides·A BjurholmM Schultzberg
Jul 1, 1972·American Journal of Orthodontics·J F Durkin
Nov 1, 1994·Journal of Neurobiology·A M Davies
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Apr 1, 1995·Journal of Neurochemistry·C Lomen-Hoerth, E M Shooter
Feb 15, 1994·Biochemical and Biophysical Research Communications·T NakanishiS Taniguchi
Jun 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R A DoddsM Gowen
May 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R J O'KeefeR N Rosier
Mar 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A M Davies
Dec 1, 1996·Acta Orthopaedica Scandinavica·Y KonttinenA Suda
Aug 1, 1997·European Journal of Oral Sciences·X SiF H White
Feb 7, 1998·Cell and Tissue Research·C A NosratL Olson
May 16, 1998·Biochemical and Biophysical Research Communications·K NemotoT Ueyama
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevA R Paus
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·S J MiknyoczkiB A Ruggeri
Jun 5, 1999·Brain Research Bulletin·M QuartuM Del Fiacco

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Citations

Apr 9, 2008·The Journal of Biological Chemistry·Mikihito KajiyaHidemi Kurihara
Nov 2, 2005·Tissue Engineering·Katsuhiro TakedaHidemi Kurihara
Aug 30, 2008·Arthritis Research & Therapy·Devina PurmessurJudith A Hoyland
Feb 18, 2014·International Immunopharmacology·Mikihito KajiyaHidemi Kurihara
Jul 6, 2014·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Olaf KilianKatrin Susanne Lips
Jan 9, 2014·Rheumatology International·Adriano Prado SimãoAna Cristina Rodrigues Lacerda
Oct 28, 2016·Endocrine·Giovanni LombardiGiuseppe Banfi
Nov 8, 2015·Bone·Natalie K Y WeePaul A Baldock
May 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fei-Yan DengHong-Wen Deng
Aug 28, 2009·Journal of Cellular Physiology·Mikihito KajiyaHidemi Kurihara
Jan 15, 2015·Mediators of Inflammation·Jôice Dias CorrêaTarcília Aparecida da Silva
Apr 4, 2017·Journal of Cellular Physiology·Yu-Wen SuCory J Xian
Feb 23, 2019·Frontiers in Endocrinology·Giovanni LombardiGiuseppe Banfi
Sep 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thomas Leonhard LoyKatrin Susanne Lips
Nov 9, 2015·Molecular and Cellular Biochemistry·Daisuke TsunodaNoriyuki Koibuchi
Jan 8, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hiroaki NakamuraToshio Yamamoto
Jun 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vivien KauschkeKatrin Susanne Lips

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